Recommendations made
pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.
Is it allowed to take Ketoconazole during lactation? |
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A high protein-binding capacity may explain its low excretion into breastmilk observed after oral administration. Low levels that would reach the infant’s gut through breastmilk would barely be absorbed due to the alkaline environment that hinders the absorption. Because it is topically used on creams or vaginal ovules, it would have a low or nil absorption in mother’s plasma (Ene 1984, AEMPS 2015), hence, the amount excreted in milk is expected to be even lower than that following a systemic administration. It would be wise to avoid applying creams, gels and other topical products containing paraffin (mineral oil) on the nipple so that the infant could not ingest it (Noti 2003, Concin 2008). American Academy of Pediatrics: medication usually compatible with breastfeeding. |
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Would you like to ask something else about Ketoconazole ? |
Types of risk
VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...
LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...
HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...
VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...
Trade Names
The main trade names in different countries containing in its composition Ketoconazole:- Arcolane ™
- Extina ™
- Freetop ™
- Fungarest ™
- Fungistab (Фунгистаб) ™
- Fungo Zeus ™
- Fungoral ™
- Keduo ™
- Kenazol ™
- Kenazole (Кеназол) ™
- Ketazol ™
- Keto-Cure ™
- Ketodan ™
- Ketoderm ™
- Ketodin (Кетодин) ™
- Ketogeno ™
- Ketolef ™
- Ketomed ™
- Ketonazol ™
- Ketozol ™
- Ketozole ™
- Ketozoral (Кетозорал) ™
- Kexin (可欣) ™
- Konact ™
- Livarol (Ливарол) ™
- Livarole (Ливарол) ™
- Medezol ™
- Mycoket (Микокет) ™
- Mycosoral (Микозорал) ™
- Nizoral ™
- Nizoral (Низорал) ™
- Nizoral (里素劳) ™
- Oronazol (Ороназол) ™
- Perkhotal (Перхотал) ™
- Pikangwang (皮康王) ™
- Samkol ™
- Sebozole (Себозол) ™
- Terzolin ™
- Triatop (采乐) ™
- Xolegel ™
Scientific literature
The level of risk for breastfeeding is confirmed in these scientific publications:- http://www.ncbi.nlm.nih.gov/pubmed/24528912
- http://www.ncbi.nlm.nih.gov/pubmed/17923223
- http://www.ncbi.nlm.nih.gov/pubmed/16677965
- http://www.ncbi.nlm.nih.gov/pubmed/14623482
- http://www.ncbi.nlm.nih.gov/pubmed/11533352
- http://pediatrics.aappublications.org/content/108/3/776.full.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/11847833
- http://www.ncbi.nlm.nih.gov/pubmed/7503214
- http://www.ncbi.nlm.nih.gov/pubmed/1406784
- http://www.ncbi.nlm.nih.gov/pubmed/3767339
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC180519/pdf/aac00163-0022.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/6322829
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1463314/pdf/brjclinpharm00164-0057.pdf
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