Recommendations made
pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.
Is it allowed to take Chloramphenicol (topical use) during lactation? |
|
Topically used to treat cutaneous, eye and ear infections. The small dose used and poor plasma uptake of most topical ophthalmic and dermal preparations make it very unlikely that a significant amount would pass into breast milk.Plasma levels after topical application on skin are 1000 times lower than those observed after systemic administration (Fluhr 1998).Possible absorption following ophthalmologic administration could be minimized by following appropriate ophthalmologist instructions (eg finger-compression on the tear sac at the internal eye’s corner for one minute after application of drops)Even after been taken systemically (orally or parenterally), the excretion into breastmilk is poor, which would impede the development of neonatal gray syndrome. Do not apply on the chest to prevent the infant from ingesting it. Otherwise, apply it after a breast feeding and clean it up thoroughly with water before the next feeding. |
|
Would you like to ask something else about Chloramphenicol (topical use) ? |
Types of risk
VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...
LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...
HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...
VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...
Trade Names
The main trade names in different countries containing in its composition Chloramphenicol (topical use):Scientific literature
The level of risk for breastfeeding is confirmed in these scientific publications:- http://www.ncbi.nlm.nih.gov/pubmed/16648419
- http://www.ncbi.nlm.nih.gov/pubmed/12431134
- http://www.ncbi.nlm.nih.gov/pubmed/11847854
- http://www.ncbi.nlm.nih.gov/pubmed/9541732
- http://www.ncbi.nlm.nih.gov/pubmed/9596854
- http://www.ncbi.nlm.nih.gov/pubmed/6743732
- http://www.ncbi.nlm.nih.gov/pubmed/6868331
- http://www.ncbi.nlm.nih.gov/pubmed/7182457
- http://www.ncbi.nlm.nih.gov/pubmed/7273601
- http://www.ncbi.nlm.nih.gov/pubmed/7362398
- http://www.ncbi.nlm.nih.gov/pubmed/525980
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC352732/pdf/aac00275-0027.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/508680
- http://www.ncbi.nlm.nih.gov/pubmed/5750653
Comments