Synthetic drug analog to vitamin D3 which is similar to calcitriol.It is topically used on the treatment of psoriasis. At latest update relevant published data on excretion into breast milk were not found. Due to a poor gut absorption, plasma levels were undetectable or very low (AEMPS 2014), so it is unlikely a passage in significant amounts into breastmilk.In addition, it is a derivative of vitamin D3 with poor effect on calcium metabolism. No significant changes on calcium plasma levels have been observed, whenever compliance with the maximum recommended doses is followed (Murdoch 1992, Bourke 1993 and 1997, Blum 1998). Therefore, several consensus of experts accept the use of Calcipotriol as safe while breastfeeding (Zip 2002, Leachman 2006, Strober 2009, Barrett 2013, Butler 2014) which can even be applied to the nipple whenever necessary (Barrett 2013 ).It can be applied for long time periods during breastfeeding provided it would not cover more than 20% of body surface area (Barrett 2013). It should be avoided application on the nipple of creams, gels and other topical containing-paraffin products (mineral oil) so that the infant would not absorb them (Noti 2003, Concin 2008).In case of psoriasis of the nipple it should be applied after a feeding at breast followed by a thoroughly cleaning up with water before the next feeding.