Recommendations made
pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.
Is it allowed to take Goserelin during lactation? |
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It is a GNRH analogue that works like an inhibitor of Hypophysis Gonadotropin (LH & FSH) secretion. A continue use produces a decrease of Estradiol level to those seen during the post-menopause period. A decrease of breast milk production is possible. When used for the treatment of infertility, the anovulatory effect of breastfeeding should be taken into account, if it is done with a frequent on-demand feeding. At latest update, no relevant published data concerning excretion into breast milk were found. Its high molecular weight makes excretion into breast milk be unlikely. Also, a low oral bioavailability renders the absorption of this agent into the infant's plasma be nil or minimal. |
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Would you like to ask something else about Goserelin ? |
Types of risk
VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...
LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...
HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...
VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...
Trade Names
The main trade names in different countries containing in its composition Goserelin:Scientific literature
The level of risk for breastfeeding is confirmed in these scientific publications:- http://www.pdr.net/drug-summary/zoladex-implant-36-mg?druglabelid=1129&id=2800&mode=preview
- http://www.aemps.gob.es/cima/pdfs/es/ft/58603/FT_58603.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/10926349
- http://www.ncbi.nlm.nih.gov/pubmed/9496328
- http://www.fertstert.org/article/S0015-0282(97)00502-5/pdf
- http://www.ncbi.nlm.nih.gov/pubmed/8808170
- http://www.ncbi.nlm.nih.gov/pubmed/7847108
- http://www.ncbi.nlm.nih.gov/pubmed/1709853