Third generation cephalosporins for oral administration. At latest update no published data on excretion into breast milk were found. Most cephalosporins are excreted into milk in insignificant amounts from a therapeutic point of view without reported complications in infants.Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant. Pharmacokinetic data (moderately high molecular weight, high protein binding capacity and short half-life span) make unlikely the milk passage of significant amounts into breast milk.Their low oral bioavailability hinders the passage from ingested milk to the infant’s plasma except in preterm babies and immediate neonatal period, when they may exhibit an increased intestinal permeability. Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.