Quinolone-related medication has been used in neonates and infants without known side effects. It is excreted in tiny amounts into breast milk. Absorption through the child’s gut may be interfered by calcium in the milk. Should it be prescribed to a nursing mother Norfloxacine, Ofloxacine and Ciprofloxacine are to be chosen since they have shown a lowest excretion into the milk. One case of pseudomembranose colitis, possibly related to mother ingestion of Ciporfloxacine, in a premature infant has been described who previously was affected of NEC, Follow-up for diarrhea in the infant is warranted. Be aware of false negative bacterial cultures in the infant when the mother is on antibiotics. The American Academy of Pediatrics rates it compatible with breastfeeding.