Some published studies indicate that Norfloxacin is not excreted into breast milk. A short half life and low oral bioavailability are characteristics that suggest it is the safest quinolone-type antimicrobial to be used while breastfeeding. Quinolone antibiotics are being used to treat infection in newborn infants without side effect reported. A small amount pass into breast milk but absorption by the child's gut is thought would be interfered by the calcium present in the milk. Should Fluor-quinolone medication be used in breastfeeding mothers, Nofloxacin, Ofloxacin and Ciprofloxacin are considered to be of choice because a lower concentration in mother's serum. Follow-up of the child for the appearance of diarrhea is recommended since one case of Colitis pseudomembranosa occurred in a breastfed child who was born premature and complicated with Necrotizing Enterocolitis. Consider the possibility of false negative results of urine cultures among breastfed infants from treated mothers who are febrile.