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pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.


woomen

Is it allowed to take Adalimumab during lactation?
Is it safe for a nursing mother and a child?

IgG1-monoclonal antibody directed against tumor necrosis factor used for treatment of auto-immune diseases like Rheumatoid Arthritis. Minimal or low excretion into breast milk due to high molecular weight. In breastfed babies whose mothers were on this medication plasma levels were undetectable and failed to show side effects. It should be avoid in the first two post-partum weeks since pass of significant amounts of IgG to the milk can occur in the first 3 - 4 post-partum days.

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woomen

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Types of risk

VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...

LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...

HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...

VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...

Trade Names

The main trade names in different countries containing in its composition Adalimumab:

Scientific literature

The level of risk for breastfeeding is confirmed in these scientific publications:
  1. http://www.ncbi.nlm.nih.gov/pubmed/26888948
  2. http://ard.bmj.com/content/early/2016/02/17/annrheumdis-2015-208840.full.pdf
  3. http://www.ncbi.nlm.nih.gov/pubmed/26688268
  4. http://www.gastrojournal.org/article/S0016-5085(15)01773-4/pdf
  5. http://www.ncbi.nlm.nih.gov/pubmed/26129693
  6. http://www.ncbi.nlm.nih.gov/pubmed/25819232
  7. http://onlinelibrary.wiley.com/doi/10.1111/ddg.12596/epdf
  8. http://www.ncbi.nlm.nih.gov/pubmed/25829190
  9. http://www.reumatismo.org/index.php/reuma/article/download/reumatismo.2014.798/pdf_10
  10. http://www.ncbi.nlm.nih.gov/pubmed/25602023
  11. http://ecco-jcc.oxfordjournals.org/content/eccojc/9/2/107.full.pdf
  12. http://www.ncbi.nlm.nih.gov/pubmed/23897285
  13. http://www.ncbi.nlm.nih.gov/pubmed/24707132
  14. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974516/pdf/WJG-20-3495.pdf
  15. http://www.ncbi.nlm.nih.gov/pubmed/24964946
  16. https://s3-eu-west-1.amazonaws.com/thejournalhub/10.15570/actaapa.2014.7/actaapa.2014.7.pdf
  17. http://www.ncbi.nlm.nih.gov/pubmed/25200000
  18. http://onlinelibrary.wiley.com/doi/10.1111/apt.12949/epdf
  19. http://www.ncbi.nlm.nih.gov/pubmed/24614280
  20. http://www.ncbi.nlm.nih.gov/pubmed/24528912
  21. http://www.ncbi.nlm.nih.gov/pubmed/23200982
  22. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913646/pdf/nihms-542223.pdf
  23. http://www.ncbi.nlm.nih.gov/pubmed/23102835
  24. http://www.ncbi.nlm.nih.gov/pubmed/23749699
  25. http://medwiekurozwoj.pl/articles/2013-1-10.pdf
  26. http://www.ncbi.nlm.nih.gov/pubmed/23474350
  27. http://www.dldjournalonline.com/article/S1590-8658(13)00050-9/pdf
  28. http://www.ncbi.nlm.nih.gov/pubmed/22690068
  29. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369996/pdf/WJG-18-2600.pdf
  30. http://www.ncbi.nlm.nih.gov/pubmed/22221203
  31. http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2011.04967.x/epdf
  32. http://www.ncbi.nlm.nih.gov/pubmed/22858514
  33. http://www.ncbi.nlm.nih.gov/pubmed/22387837
  34. http://pdf.medrang.co.kr/Kjg/059/Kjg059-02-05.pdf
  35. http://www.ncbi.nlm.nih.gov/pubmed/22018758
  36. http://www.ncbi.nlm.nih.gov/pubmed/21122553
  37. http://ecco-jcc.oxfordjournals.org/content/eccojc/4/5/493.full.pdf
  38. http://www.ncbi.nlm.nih.gov/pubmed/19885906
  39. http://www.ncbi.nlm.nih.gov/pubmed/20005982
  40. http://www.ncbi.nlm.nih.gov/pubmed/21063826
  41. http://www.ncbi.nlm.nih.gov/pubmed/21172284
  42. http://download.journals.elsevierhealth.com/pdfs/journals/1873-9946/PIIS1873994609000269.pdf
  43. http://www.ncbi.nlm.nih.gov/pubmed/19505214
  44. http://www.ncbi.nlm.nih.gov/pubmed/19452290
  45. http://www.ncbi.nlm.nih.gov/pubmed/18504282
  46. http://rheumatology.oxfordjournals.org/content/47/suppl_3/iii28.full.pdf
  47. http://www.ncbi.nlm.nih.gov/pubmed/18799245
  48. http://www.ncbi.nlm.nih.gov/pubmed/17334338
  49. http://www.ncbi.nlm.nih.gov/pubmed/16917239
  50. http://www.ncbi.nlm.nih.gov/pubmed/16831611
  51. http://www.gastrojournal.org/article/S0016-5085(06)00865-1/pdf
  52. http://www.ncbi.nlm.nih.gov/pubmed/15888806

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