Recommendations made
pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.
Is it allowed to take Tinzaparin-Sodium during lactation? |
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This is a Heparin with low molecular weight. At latest update, relevant published data on its excretion into breast milk were not found. The high molecular weight of the so-called Standard or non-fragmented Heparin and others called low weight Heparins makes that excretion into breast milk very unlikely. There is published evidence of a lack of anti-coagulant activity in the serum of breastfed infants whose mothers were treated with Enoxaparin. There is scientific proof on the lack of excretion of Dalteparin into breast milk. In addition, Heparin derived drugs are inactivated in the gut and they are not absorbed at all, hence, oral bioavailability is nil. The risk of Heparin-induced Thrombocytopenia and Osteoporosis is lower with low weight Heparin among treated adults. |
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Would you like to ask something else about Tinzaparin-Sodium ? |
Types of risk
VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...
LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...
HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...
VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...
Analogues
Trade Names
The main trade names in different countries containing in its composition Tinzaparin-Sodium:Scientific literature
The level of risk for breastfeeding is confirmed in these scientific publications:- http://www.ncbi.nlm.nih.gov/pubmed/26888577
- http://www.ncbi.nlm.nih.gov/pubmed/25138263
- http://www.ncbi.nlm.nih.gov/pubmed/23702122
- http://www.ncbi.nlm.nih.gov/pubmed/23094528
- http://www.turkishjournalpediatrics.org/pediatrics/pdf/pdf_TJP_1052.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/21921048
- http://www.bloodjournal.org/content/bloodjournal/118/20/5394.full.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/21207321
- http://www.ncbi.nlm.nih.gov/pubmed/12420239
- http://www.ncbi.nlm.nih.gov/pubmed/12422463
- http://www.ncbi.nlm.nih.gov/pubmed/11736885
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2014571/pdf/bcp0052-0708.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/10724046
- http://archinte.jamanetwork.com/data/Journals/INTEMED/11959/ira90005.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/10841132
- http://www.ncbi.nlm.nih.gov/pubmed/9488787
- http://www.ncbi.nlm.nih.gov/pubmed/8763733
- http://www.ncbi.nlm.nih.gov/pubmed/1505142
- http://www.ncbi.nlm.nih.gov/pubmed/2311907
- http://www.ncbi.nlm.nih.gov/pubmed/3069439
- http://www.ncbi.nlm.nih.gov/pubmed/6993082