Drug with similar efficacy as other antidepressants with tricyclic and selective inhibitors of serotonin reuptake characteristics.Risk of abuse and dependence with addiction, which is a reason not to be authorized in many countries.Neonatal Abstinence Syndrome has been published after abusing doses (more than 100 times higher than usual) of Tianeptine during pregnancy (Bence 2016). At latest update no published data on excretion into breast milk were found. Its high plasma protein-binding capacity makes it unlikely the passage of drug into breast milk. It may, like other antidepressants, increase Prolactin levels in the plasma. Until more published data regarding breastfeeding is available, the use of a known and safer alternative drug should be preferred, especially during the neonatal period and/or in case of premature infant.