It is composed by bisphosphonates Most bisphosphonates are acidic compounds that achieve low plasma concentration. Both features make it unlikely excretion into the milk in clinically significant amount. Intestinal absorption of bisphosphonates is very low even during fasting and is considered negligible in the presence of milk due to formation with the calcium of non absorbable compounds. Pamidronate is excreted into breast milk in clinically insignificant amount and no problems have been observed in infants whose mothers were treated, except some cases of mild and asymptomatic hypocalcemia in infants whose mothers had been already treated before and / or during pregnancy, so some authors suggest regular monitoring of serum calcium.