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pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.


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Is it allowed to take Domperidone during lactation?
Is it safe for a nursing mother and a child?

Drug which has been approved to be used for vomiting relief and as prokinetic medication in many countries. Usually prescribed to infants with gastroesophageal reflux disease by pediatricians, At usual adult dose (10 mg every 8 hours 2 weeks) may increase breast milk production by stimulating Prolactin release but it does not appear in significant concentration in the milk. It does not go across the blood brain barrier (lack of neurological effect). Because of these considerations Domperidone is a more appropriate drug as galactagogue. The best way to increase milk production would be a frequent and breastfeeding on demand together with an appropriate nursing technique. Domperidone should not be used without medical supervision. It has been related to increase risk of heart rhythm disorders (e.g. severe ventricular arrhythmia) in patients older than 60 years at a dose higher than 30 mg a-day who had other cardiac conditions (e.g. prolonged-QT) and when addtional medication that prolongs the QT interval was administered. The American Academy of Pediatrics rates it compatible with breastfeeding.

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Types of risk

VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...

LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...

HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...

VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...

Trade Names

The main trade names in different countries containing in its composition Domperidone:

Scientific literature

The level of risk for breastfeeding is confirmed in these scientific publications:
  1. http://www.ncbi.nlm.nih.gov/pubmed/24147629
  2. http://www.ncbi.nlm.nih.gov/pubmed/22554679
  3. http://www.ncbi.nlm.nih.gov/pubmed/23015150
  4. http://www.ncbi.nlm.nih.gov/pubmed/23277457
  5. http://www.ncbi.nlm.nih.gov/pubmed/23940477
  6. http://www.ncbi.nlm.nih.gov/pubmed/23178070
  7. http://www.ncbi.nlm.nih.gov/pubmed/23968886
  8. http://www.ncbi.nlm.nih.gov/pubmed/23979084
  9. http://pediatrics.aappublications.org/content/132/3/e796.full.pdf
  10. http://www.ncbi.nlm.nih.gov/pubmed/22220176
  11. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246777/pdf/OGI2012-562704.pdf
  12. http://www.ncbi.nlm.nih.gov/pubmed/22224508
  13. http://www.ncbi.nlm.nih.gov/pubmed/22147287
  14. http://www.ncbi.nlm.nih.gov/pubmed/22189066
  15. http://www.ncbi.nlm.nih.gov/pubmed/22419310
  16. http://www.ncbi.nlm.nih.gov/pubmed/22461793
  17. http://www.ncbi.nlm.nih.gov/pubmed/22935052
  18. http://www.ncbi.nlm.nih.gov/pubmed/22972723
  19. http://www.ncbi.nlm.nih.gov/pubmed/23012383
  20. http://www.ncbi.nlm.nih.gov/pubmed/22724311
  21. http://www.ncbi.nlm.nih.gov/pubmed/21254794
  22. http://online.liebertpub.com/doi/pdfplus/10.1089/bfm.2010.0062
  23. http://www.ncbi.nlm.nih.gov/pubmed/21739859
  24. http://www.ncbi.nlm.nih.gov/pubmed/22048759
  25. http://www.ncbi.nlm.nih.gov/pubmed/21894275
  26. http://www.racgp.org.au/download/documents/AFP/2011/September/201109amir.pdf
  27. http://www.bfmed.org/Media/Files/Protocols/Spanish%20Protocol%20Galactogogues%20and%20Appendix.pdf
  28. http://www.ncbi.nlm.nih.gov/pubmed/21332371
  29. http://online.liebertpub.com/doi/pdfplus/10.1089/bfm.2011.9998
  30. http://www.ncbi.nlm.nih.gov/pubmed/20008425
  31. http://www.ncbi.nlm.nih.gov/pubmed/20571140
  32. http://www.ncbi.nlm.nih.gov/pubmed/20816003
  33. http://ejournals.library.ualberta.ca/index.php/JPPS/article/download/6663/7429
  34. http://www.ncbi.nlm.nih.gov/pubmed/18974293
  35. http://www.ncbi.nlm.nih.gov/pubmed/18507654
  36. http://www.ncbi.nlm.nih.gov/pubmed/16809652
  37. http://www.jabfm.org/content/19/4/374.full.pdf
  38. http://www.ncbi.nlm.nih.gov/pubmed/16719919
  39. http://www.ncbi.nlm.nih.gov/pubmed/16969436
  40. http://www.ncbi.nlm.nih.gov/pubmed/16831611
  41. http://www.gastrojournal.org/article/S0016-5085(06)00865-1/pdf
  42. http://www.ncbi.nlm.nih.gov/pubmed/15451832
  43. http://www.ncbi.nlm.nih.gov/pubmed/12192964
  44. http://www.ncbi.nlm.nih.gov/pubmed/11202662
  45. http://www.ncbi.nlm.nih.gov/pubmed/11533352
  46. http://pediatrics.aappublications.org/content/108/3/776.full.pdf
  47. http://www.ncbi.nlm.nih.gov/pubmed/10732318
  48. http://www.ncbi.nlm.nih.gov/pubmed/8346780
  49. http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2044.1993.tb07130.x/epdf
  50. http://www.ncbi.nlm.nih.gov/pubmed/3725173
  51. http://www.ncbi.nlm.nih.gov/pubmed/3882143
  52. http://www.ncbi.nlm.nih.gov/pubmed/3894101
  53. http://www.ncbi.nlm.nih.gov/pubmed/6131323
  54. http://www.ncbi.nlm.nih.gov/pubmed/6404476
  55. http://www.ncbi.nlm.nih.gov/pubmed/7428183

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