Recommendations made
pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.
Is it allowed to take Domperidone during lactation? |
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Drug which has been approved to be used for vomiting relief and as prokinetic medication in many countries. Usually prescribed to infants with gastroesophageal reflux disease by pediatricians, At usual adult dose (10 mg every 8 hours 2 weeks) may increase breast milk production by stimulating Prolactin release but it does not appear in significant concentration in the milk. It does not go across the blood brain barrier (lack of neurological effect). Because of these considerations Domperidone is a more appropriate drug as galactagogue. The best way to increase milk production would be a frequent and breastfeeding on demand together with an appropriate nursing technique. Domperidone should not be used without medical supervision. It has been related to increase risk of heart rhythm disorders (e.g. severe ventricular arrhythmia) in patients older than 60 years at a dose higher than 30 mg a-day who had other cardiac conditions (e.g. prolonged-QT) and when addtional medication that prolongs the QT interval was administered. The American Academy of Pediatrics rates it compatible with breastfeeding. |
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Types of risk
VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...
LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...
HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...
VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...
Trade Names
The main trade names in different countries containing in its composition Domperidone:Scientific literature
The level of risk for breastfeeding is confirmed in these scientific publications:- http://www.ncbi.nlm.nih.gov/pubmed/24147629
- http://www.ncbi.nlm.nih.gov/pubmed/22554679
- http://www.ncbi.nlm.nih.gov/pubmed/23015150
- http://www.ncbi.nlm.nih.gov/pubmed/23277457
- http://www.ncbi.nlm.nih.gov/pubmed/23940477
- http://www.ncbi.nlm.nih.gov/pubmed/23178070
- http://www.ncbi.nlm.nih.gov/pubmed/23968886
- http://www.ncbi.nlm.nih.gov/pubmed/23979084
- http://pediatrics.aappublications.org/content/132/3/e796.full.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/22220176
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246777/pdf/OGI2012-562704.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/22224508
- http://www.ncbi.nlm.nih.gov/pubmed/22147287
- http://www.ncbi.nlm.nih.gov/pubmed/22189066
- http://www.ncbi.nlm.nih.gov/pubmed/22419310
- http://www.ncbi.nlm.nih.gov/pubmed/22461793
- http://www.ncbi.nlm.nih.gov/pubmed/22935052
- http://www.ncbi.nlm.nih.gov/pubmed/22972723
- http://www.ncbi.nlm.nih.gov/pubmed/23012383
- http://www.ncbi.nlm.nih.gov/pubmed/22724311
- http://www.ncbi.nlm.nih.gov/pubmed/21254794
- http://online.liebertpub.com/doi/pdfplus/10.1089/bfm.2010.0062
- http://www.ncbi.nlm.nih.gov/pubmed/21739859
- http://www.ncbi.nlm.nih.gov/pubmed/22048759
- http://www.ncbi.nlm.nih.gov/pubmed/21894275
- http://www.racgp.org.au/download/documents/AFP/2011/September/201109amir.pdf
- http://www.bfmed.org/Media/Files/Protocols/Spanish%20Protocol%20Galactogogues%20and%20Appendix.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/21332371
- http://online.liebertpub.com/doi/pdfplus/10.1089/bfm.2011.9998
- http://www.ncbi.nlm.nih.gov/pubmed/20008425
- http://www.ncbi.nlm.nih.gov/pubmed/20571140
- http://www.ncbi.nlm.nih.gov/pubmed/20816003
- http://ejournals.library.ualberta.ca/index.php/JPPS/article/download/6663/7429
- http://www.ncbi.nlm.nih.gov/pubmed/18974293
- http://www.ncbi.nlm.nih.gov/pubmed/18507654
- http://www.ncbi.nlm.nih.gov/pubmed/16809652
- http://www.jabfm.org/content/19/4/374.full.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/16719919
- http://www.ncbi.nlm.nih.gov/pubmed/16969436
- http://www.ncbi.nlm.nih.gov/pubmed/16831611
- http://www.gastrojournal.org/article/S0016-5085(06)00865-1/pdf
- http://www.ncbi.nlm.nih.gov/pubmed/15451832
- http://www.ncbi.nlm.nih.gov/pubmed/12192964
- http://www.ncbi.nlm.nih.gov/pubmed/11202662
- http://www.ncbi.nlm.nih.gov/pubmed/11533352
- http://pediatrics.aappublications.org/content/108/3/776.full.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/10732318
- http://www.ncbi.nlm.nih.gov/pubmed/8346780
- http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2044.1993.tb07130.x/epdf
- http://www.ncbi.nlm.nih.gov/pubmed/3725173
- http://www.ncbi.nlm.nih.gov/pubmed/3882143
- http://www.ncbi.nlm.nih.gov/pubmed/3894101
- http://www.ncbi.nlm.nih.gov/pubmed/6131323
- http://www.ncbi.nlm.nih.gov/pubmed/6404476
- http://www.ncbi.nlm.nih.gov/pubmed/7428183