IL-enantiomer of Sulpiride. Both share similar characteristics and properties. More frequently used as anti-emetic and prokinetic than as anti-psychotic agent. Sulpiride is a Dopamine-selective antagonist that increases Prolactin serum levels which is used as anti-psychotic, anti-depressant, anti-emetic and prokinetic agent. Its property as galactogogue has been questioned because poor methodology used by published studies that intended to prove it. Doses at 50 mg twice-a-day after early post-partum for four weeks have been used to stimulate initiation of lactation without adverse effects in the mother. Excretion into breast milk is moderate, however, side-effects in breastfed infants from treated mothers were not observed. Best galactagogue effect is attained by promoting frequent breastfeeding on-demand along with the use of a proper lactation technique. Effective support to breastfeeding mothers, woman empowerment related to her ability to breastfeed and self-confidence are important factors to reinforce before start using galactagogue drugs.