It increases renal excretion of Uric acid and decreases elimination of many drug by the kidneys, among them beta-lactam antibiotics, with augmented plasma levels and effectiveness. Excretion into breast milk is clinically non-significant, with no problems observed among breastfed infants from treated mothers that could be attributed to Probenecid (reportedly, one case of self-limited diarrhea occurred in a child whose mother was taking a Cephalosporin together with Probenecid).