Fibrinolytic enzyme obtained from hemolytic streptococcus strains. It is used topically with streptokinase to remove clots or purulent material from wounds or cavities (pleura, bladder). There is no scientific support for the effectiveness of its oral administration, since there is evidence of its lack of oral absorption and absence of fibrinolytic properties when taken orally (Oliven 1981, Vonmoos 1979). Since the last update we have not found published data on its excretion in breast milk, but given the lack of absorption when taken orally it is unlikely to be excreted in breast milk in significant amounts which furthermore would not be absorbed in the infant’s intestine.