It is excreted into breast milk in clinically non-significant amount, in fact a much lower amount than the dose used for the treatment or prophylaxis of infection in neonates and infants. Even more, no problems that would be attributable to rifampicin have been observed among infants whose mothers were taking this medication. It can cause an orange discoloration of body fluids, including the mother’s milk.Take into account possible negative results in bacterial cultures of febrile infants, when their mothers are on antibiotics. American Academy of Pediatrics states that it is usually compatible with breastfeeding medication.WHO List of Essential Medicines 2002: compatible with breastfeeding.