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Recommendations made
pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.


Is it allowed to take Acetiamine Hydrochloride during lactation?
Is it safe for a nursing mother and a child?

Thiamine or Vitamin B1 is a water soluble vitamin. In addition to Thiamine, other chemical compounds with similar activity: Acetiamine, Benfotiamine, Bisbentiamine, Bisbutiamina, Cetotiamina, Cicotiamina, Cocarboxylase, Fursultiamine, Monofosfotiamina, Octotiamine, Pyrophosphotiamine, Prosultiamine and Sulbutiamine.It is essential for the metabolism of carbohydrate nutrients. Its deficiency causes severe neuromuscular and cardiac symptoms known as Beriberi and Wernicke-Korsakoff disease. Thiamine deficiency is common among disadvantaged populations in Southeast Asia (predominantly consumers of refined rice), other malnourished people (refugees, low socioeconomic status ...) and chronic alcohol consumption. Beriberi of childhood, both infants and children, may arise from breastfeeding by Thiamine deficient mothers. Reportedly, several severe cases have occured after feeding the babies with artificial formulas that were not supplemented with vitamin B1. Daily allowance is higher during pregnancy and lactation (1.5 mg / day) which is readily obtained through a varied diet with adequate content of whole grains, legumes, nuts, eggs and lean meat.Thiamine is excreted in breast milk and gradually increases with time, being lower in colostrum (28 ng / mL) and transitional milk than in mature milk (180 ng / mL). The concentration is lower in milk from mothers of preterm (90 ng / mL). Taking vitamin supplementation is not required if diet and nutritional status are adequate. Supplementation does not increase levels in milk of well-nourished women, but of those with a low nutritional status. The supplementation of group B vitamins and C and E vitamins to HIV positive mothers improves the weight growth of their breasted babies.There is no evidence of their effectiveness in improving athletic performance, lack of appetite, sores, stress, fatigue or aging.Toxicity linked to excessive consumption of thiamine is not known. WHO List of Essential Medicines 2002: compatible with breastfeeding.American Academy of Pediatrics: usually compatible with breastfeeding



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Types of risk

It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...

Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...

An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...

It is not recommended. You need to stop breastfeeding or choose a safe analog. more...

Scientific literature

The level of risk for breastfeeding is confirmed in these scientific publications:
  1. http://www.ncbi.nlm.nih.gov/pubmed/26186707
  2. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505892/pdf/pone.0133285.pdf
  3. http://www.ncbi.nlm.nih.gov/pubmed/26383056
  4. http://www.elsevier.es/en/linksolver/ft/pii/S1695-4033(15)00305-7
  5. http://www.ncbi.nlm.nih.gov/pubmed/26383056
  6. http://www.ncbi.nlm.nih.gov/pubmed/24636593
  7. http://www.ncbi.nlm.nih.gov/pubmed/23864540
  8. http://ajcn.nutrition.org/content/98/3/839.full.pdf
  9. http://www.ncbi.nlm.nih.gov/pubmed/23902781
  10. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510948/pdf/nihms707918.pdf
  11. http://www.ncbi.nlm.nih.gov/pubmed/22585913
  12. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649471/pdf/362.pdf
  13. http://www.ncbi.nlm.nih.gov/pubmed/21786020
  14. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366289/pdf/394_2011_Article_226.pdf
  15. http://www.ncbi.nlm.nih.gov/pubmed/22768031
  16. http://www.ncbi.nlm.nih.gov/pubmed/22699764
  17. http://www.karger.com/Article/Pdf/338211
  18. http://www.ncbi.nlm.nih.gov/pubmed/19934228
  19. http://www.ncbi.nlm.nih.gov/pubmed/22296250
  20. http://onlinelibrary.wiley.com/doi/10.1111/j.1740-8709.2010.00276.x/epdf
  21. http://www.ncbi.nlm.nih.gov/pubmed/15817867
  22. http://ajcn.nutrition.org/content/81/4/880.full.pdf
  23. http://www.ncbi.nlm.nih.gov/pubmed/15687431
  24. http://www.ncbi.nlm.nih.gov/pubmed/14615325
  25. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1126871/
  26. http://whqlibdoc.who.int/hq/2002/55732.pdf
  27. http://www.ncbi.nlm.nih.gov/pubmed/11533352
  28. http://pediatrics.aappublications.org/content/108/3/776.full.pdf
  29. http://www.ncbi.nlm.nih.gov/pubmed/11339161
  30. http://www.ncbi.nlm.nih.gov/pubmed/11722964
  31. http://ajcn.nutrition.org/content/74/6/808.full.pdf
  32. http://www.ncbi.nlm.nih.gov/pubmed/11722950
  33. http://ajcn.nutrition.org/content/74/6/712.full.pdf
  34. http://www.ncbi.nlm.nih.gov/pubmed/9410922
  35. http://www.ncbi.nlm.nih.gov/pubmed/8929745
  36. http://www.ncbi.nlm.nih.gov/pubmed/8436160
  37. http://www.ncbi.nlm.nih.gov/pubmed/1421919
  38. http://www.ncbi.nlm.nih.gov/pubmed/3728001
  39. http://www.ncbi.nlm.nih.gov/pubmed/6859917
  40. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1627853/pdf/archdisch00746-0055.pdf
  41. http://www.ncbi.nlm.nih.gov/pubmed/6114404
  42. http://www.ncbi.nlm.nih.gov/pubmed/7424809
  43. http://www.ncbi.nlm.nih.gov/pubmed/7355793

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