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pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.


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Is it allowed to take Amethopterin during lactation?
Is it safe for a nursing mother and a child?

After a single dose of 65 mg (50 mg/square meter of body surface) as used for abortion no trace has been found in mother’s milk. For this reason it is considered to be safe for the infant while nursing under such an instance. Some authors considered it also to be safe when used on a weekly basis for the long-term treatment of Rheumatoid Arthritis and other Auto-immune diseases since few or nil presence in mother’s milk has been shown, although blood level testing in the infant is recommended. It can minimize exposure interrupting breastfeeding 24 hours after taking the drug, removing and discarding the milk. It is not recommended to nurse when used for treatment of cancer. Drug is cleared from the body after 6 elimination half-lives. Resuming breastfeeding after 4 days of breast milk pump and dump is likely safe .

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woomen

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Types of risk

VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...

LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...

HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...

VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...

Scientific literature

The level of risk for breastfeeding is confirmed in these scientific publications:
  1. http://www.ncbi.nlm.nih.gov/pubmed/28092212
  2. http://www.ncbi.nlm.nih.gov/pubmed/26750124
  3. http://rheumatology.oxfordjournals.org/content/early/2016/01/12/rheumatology.kev404.full.pdf
  4. http://www.ncbi.nlm.nih.gov/pubmed/26888948
  5. http://ard.bmj.com/content/early/2016/02/17/annrheumdis-2015-208840.full.pdf
  6. http://www.ncbi.nlm.nih.gov/pubmed/27027799
  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860651/pdf/bfm.2016.0042.pdf
  8. http://www.ncbi.nlm.nih.gov/pubmed/26688268
  9. http://www.gastrojournal.org/article/S0016-5085(15)01773-4/pdf
  10. http://www.ncbi.nlm.nih.gov/pubmed/26888577
  11. http://www.ncbi.nlm.nih.gov/pubmed/26966579
  12. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757692/pdf/MSI2016-6527458.pdf
  13. http://www.ncbi.nlm.nih.gov/pubmed/25385050
  14. http://onlinelibrary.wiley.com/doi/10.1002/acr.22516/epdf
  15. http://www.ncbi.nlm.nih.gov/pubmed/25602023
  16. http://ecco-jcc.oxfordjournals.org/content/eccojc/9/2/107.full.pdf
  17. http://www.ncbi.nlm.nih.gov/pubmed/26241432
  18. http://www.ncbi.nlm.nih.gov/pubmed/25819232
  19. http://onlinelibrary.wiley.com/doi/10.1111/ddg.12596/epdf
  20. http://www.ncbi.nlm.nih.gov/pubmed/25424052
  21. http://www.tandfonline.com/doi/full/10.3109/09546634.2014.991673
  22. http://www.ncbi.nlm.nih.gov/pubmed/26129693
  23. http://www.ncbi.nlm.nih.gov/pubmed/24614280
  24. http://www.ncbi.nlm.nih.gov/pubmed/23897285
  25. http://www.ncbi.nlm.nih.gov/pubmed/24964946
  26. https://s3-eu-west-1.amazonaws.com/thejournalhub/10.15570/actaapa.2014.7/actaapa.2014.7.pdf
  27. http://www.ncbi.nlm.nih.gov/pubmed/24528912
  28. http://www.ncbi.nlm.nih.gov/pubmed/24707132
  29. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974516/pdf/WJG-20-3495.pdf
  30. http://www.ncbi.nlm.nih.gov/pubmed/25200000
  31. http://onlinelibrary.wiley.com/doi/10.1111/apt.12949/epdf
  32. http://www.ncbi.nlm.nih.gov/pubmed/25362724
  33. http://www.jrheum.org/content/41/11/2332.full.pdf
  34. http://www.ncbi.nlm.nih.gov/pubmed/23199900
  35. http://www.ncbi.nlm.nih.gov/pubmed/23474350
  36. http://www.dldjournalonline.com/article/S1590-8658(13)00050-9/pdf
  37. http://www.ncbi.nlm.nih.gov/pubmed/23749699
  38. http://medwiekurozwoj.pl/articles/2013-1-10.pdf
  39. http://www.ncbi.nlm.nih.gov/pubmed/23849842
  40. http://www.ncbi.nlm.nih.gov/pubmed/23470115
  41. http://sogc.org/wp-content/uploads/2013/04/gui288CPG1303E.pdf
  42. http://www.ncbi.nlm.nih.gov/pubmed/22387837
  43. http://pdf.medrang.co.kr/Kjg/059/Kjg059-02-05.pdf
  44. http://www.ncbi.nlm.nih.gov/pubmed/22071804
  45. http://www.ncbi.nlm.nih.gov/pubmed/19885906
  46. http://www.ncbi.nlm.nih.gov/pubmed/21122553
  47. http://ecco-jcc.oxfordjournals.org/content/eccojc/4/5/493.full.pdf
  48. http://www.ncbi.nlm.nih.gov/pubmed/21044438
  49. http://www.ncbi.nlm.nih.gov/pubmed/21172284
  50. http://download.journals.elsevierhealth.com/pdfs/journals/1873-9946/PIIS1873994609000269.pdf
  51. http://www.ncbi.nlm.nih.gov/pubmed/19505214
  52. http://www.ncbi.nlm.nih.gov/pubmed/19772806
  53. http://www.clinexprheumatol.org/article.asp?a=3
  54. http://www.ncbi.nlm.nih.gov/pubmed/18799245
  55. http://www.ncbi.nlm.nih.gov/pubmed/17599074
  56. http://www.ncbi.nlm.nih.gov/pubmed/18239407
  57. http://www.ncbi.nlm.nih.gov/pubmed/17661756
  58. http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2007.03397.x/epdf
  59. http://www.ncbi.nlm.nih.gov/pubmed/17599074
  60. http://www.ncbi.nlm.nih.gov/pubmed/16712713
  61. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1526635/pdf/ar1957.pdf
  62. http://www.ncbi.nlm.nih.gov/pubmed/16194696
  63. http://whqlibdoc.who.int/hq/2002/55732.pdf
  64. http://www.ncbi.nlm.nih.gov/pubmed/11013791
  65. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2145042/pdf/canfamphys00031-0055.pdf
  66. http://www.ncbi.nlm.nih.gov/pubmed/10724046
  67. http://archinte.jamanetwork.com/data/Journals/INTEMED/11959/ira90005.pdf
  68. http://www.ncbi.nlm.nih.gov/pubmed/23282454
  69. http://www.ncbi.nlm.nih.gov/pubmed/2657891
  70. http://www.ncbi.nlm.nih.gov/pubmed/5042796

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