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Recommendations made
pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.


woomen

Is it allowed to take Amitriptyline Embonate during lactation?
Is it safe for a nursing mother and a child?

It is excreted into breastmilk in a clinically non-significant amount (Bader 1980, Brixen 1982, Pittard 1986, Breyer 1995, Yoshida 1999). Plasma levels in the infant have been found undetectable (Ericsson 1979, Bader 1980, Brixen 1982, Breyer 1995) or very low (Yoshida 1997) and no side effects being observed even at maternal doses as high as 150-175 mg / day (Brixen 1982 , Misri 1991, Yoshida 1999, Nulman 2002).However, one published case of sedation on a 15-day-old infant that occured within few days after taken just 10 mg daily of amitriptyline by her mother because of insomnia and anxiety (Oguz 2016). Levels were not measured in either milk or plasma of the infant and the mother. Amitriptyline may produce galactorrhoea by prolactin stimulation.

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woomen

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Types of risk

VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...

LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...

HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...

VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...

Scientific literature

The level of risk for breastfeeding is confirmed in these scientific publications:
  1. http://www.ncbi.nlm.nih.gov/pubmed/27870551
  2. http://www.ncbi.nlm.nih.gov/pubmed/26204124
  3. https://abm.memberclicks.net/assets/DOCUMENTS/PROTOCOLS/18-use-of-antidepressants-protocol-english.pdf
  4. http://www.ncbi.nlm.nih.gov/pubmed/25217187
  5. http://www.ncbi.nlm.nih.gov/pubmed/22787503
  6. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394379/pdf/Dtsch_Arztebl_Int-109-0419.pdf
  7. http://www.ncbi.nlm.nih.gov/pubmed/22683887
  8. http://www.ncbi.nlm.nih.gov/pubmed/22283766
  9. http://www.ncbi.nlm.nih.gov/pubmed/22683887
  10. http://www.ncbi.nlm.nih.gov/pubmed/20958101
  11. http://www.ncbi.nlm.nih.gov/pubmed/20807106
  12. http://www.ncbi.nlm.nih.gov/pubmed/20543503
  13. http://www.ncbi.nlm.nih.gov/pubmed/20662551
  14. http://www.ncbi.nlm.nih.gov/pubmed/18333769
  15. http://online.liebertpub.com/doi/pdfplus/10.1089/bfm.2007.9978
  16. http://www.ncbi.nlm.nih.gov/pubmed/16831611
  17. http://www.gastrojournal.org/article/S0016-5085(06)00865-1/pdf
  18. http://www.ncbi.nlm.nih.gov/pubmed/15169695
  19. http://ajp.psychiatryonline.org/doi/pdf/10.1176/appi.ajp.161.6.1066
  20. http://www.ncbi.nlm.nih.gov/pubmed/14749550
  21. http://www.ncbi.nlm.nih.gov/pubmed/15591613
  22. http://www.ncbi.nlm.nih.gov/pubmed/14645327
  23. http://www.jabfm.org/content/16/5/372.full.pdf
  24. http://whqlibdoc.who.int/hq/2002/55732.pdf
  25. http://www.ncbi.nlm.nih.gov/pubmed/12411224
  26. http://www.ncbi.nlm.nih.gov/pubmed/10221361
  27. http://www.ncbi.nlm.nih.gov/pubmed/9296322
  28. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2042834/pdf/bcp_0652.pdf
  29. http://www.ncbi.nlm.nih.gov/pubmed/9441422
  30. http://www.ncbi.nlm.nih.gov/pubmed/9186793
  31. http://www.ncbi.nlm.nih.gov/pubmed/8780414
  32. http://www.ncbi.nlm.nih.gov/pubmed/7726331
  33. http://www.ncbi.nlm.nih.gov/pubmed/7834964
  34. http://www.ncbi.nlm.nih.gov/pubmed/1894455
  35. http://www.ncbi.nlm.nih.gov/pubmed/3805339
  36. http://www.ncbi.nlm.nih.gov/pubmed/6805016
  37. http://www.ncbi.nlm.nih.gov/pubmed/7386673
  38. http://www.ncbi.nlm.nih.gov/pubmed/495815
  39. http://www.ncbi.nlm.nih.gov/pubmed/4560178

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