Recommendations made
pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.
Is it allowed to take Atlizumab during lactation? |
|
Monoclonal antibody that inhibits the Interleukin-6 receptor (IL-6r) which is used for treatment of Rheumatoid Arthritis, some types of Juvenile Arthritis and Castleman's disease. At latest update no published data on excretion into breast milk were found. Its high molecular weight makes that excretion into breast milk be very unlikely. Because of a low oral bioavailability it is thought that amount absorbed to the infant's plasma from ingested breast milk would be nil or minimal, except in the immediate newborn period or in case of prematurity who may show an increased intestinal absorption. Until more data on this drug is available, it would be preferred other options that are known to be safer, specially during the neonatal period and prematurity. |
|
Would you like to ask something else about Atlizumab ? |
Types of risk
VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...
LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...
HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...
VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...
Scientific literature
The level of risk for breastfeeding is confirmed in these scientific publications:- http://www.ncbi.nlm.nih.gov/pubmed/26750124
- http://rheumatology.oxfordjournals.org/content/early/2016/01/12/rheumatology.kev404.full.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/26888948
- http://ard.bmj.com/content/early/2016/02/17/annrheumdis-2015-208840.full.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/24352337
- http://www.ncbi.nlm.nih.gov/pubmed/23782588
- http://www.ncbi.nlm.nih.gov/pubmed/21985166