I was originally prescribed colistin when my colonized bacteria proved to be pan-resistant to most other antibiotics. There had been some research suggesting colistin may be able to change resistance patterns after consistent use. In my case this proved true as after about 6 months on an alternating schedule (1 month on, 1 month off) my cultures showed that sensitivities to the more typical, modern antibiotics had increased to the point where we could treat my next exacerbation with a more standard cocktail of IV antibiotics. It definitely takes more work than Tobi or Cayston, and the nebulization time is longer, but I feel that it also has the positive side effect of treating my colonized sinus infection better than the others. I notice a significant reduction (and sometimes elimination) of any discolored mucus from my sinuses after my month on. This effect increased after I started inhaling through my mouth as usual, but always exhaling through my nose to improve distribution of the med through the sinuses. I also feel I have a better result when mixing the 150 mg powder with 5 ml of sterile water/saline compared to when it is mixed with smaller amounts of liquid. It foams less at this concentration, allowing more to be inhaled, at the cost of slightly longer nebulization times. My prescription calls for 75 mg per treatment, so I complete the use of a single 150 mg vial within 12 hours (two nebs of 2.5 ml with 75 mg colistin each time). For ease of use, if you are comfortable with a syringe and needle to transfer sterile liquid to the vial of powder, allowing it to dissolve gently, drawing out the correct amount and refrigerating the rest (and using or disposing within 24 hours), it takes time, but is not difficult.