Recommendations made
pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.
Is it allowed to take Dihydroxypropoxymethylguanine (DHPG) during lactation? |
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Synthetic nucleoside which is analogue of guanine, structurally very closed related to acyclovir.Indicated for the treatment and prevention of Cytomegalovirus (CMV) in immunocompromised patients. At latest update no published data on excretion into breast milk were found. It is used in newborns and premature who are affected with CMV infection.Its low oral bioavailability hinders the passage from ingested milk towards the infant’s plasma, except in preterm babies and immediate neonatal period, which may show an increased intestinal permeability. |
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Would you like to ask something else about Dihydroxypropoxymethylguanine (DHPG) ? |
Types of risk
VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...
LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...
HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...
VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...
Scientific literature
The level of risk for breastfeeding is confirmed in these scientific publications:- http://www.ncbi.nlm.nih.gov/pubmed/24247027
- http://www.ncbi.nlm.nih.gov/pubmed/22202955
- http://www.ncbi.nlm.nih.gov/pubmed/23016620
- http://www.tandfonline.com/doi/full/10.3109/14767058.2012.712345
- http://www.ncbi.nlm.nih.gov/pubmed/20630814
- http://www.ncbi.nlm.nih.gov/pubmed/17118633
- http://www.ncbi.nlm.nih.gov/pubmed/9129069
- http://www.ncbi.nlm.nih.gov/pubmed/7585846
- http://www.ncbi.nlm.nih.gov/pubmed/7769276
- http://www.ncbi.nlm.nih.gov/pubmed/8380762
- http://www.ncbi.nlm.nih.gov/pubmed/2847287
- http://www.ncbi.nlm.nih.gov/pubmed/2820301