Diphenylhydantoin

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Recommendations made
pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.

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Is it allowed to take Diphenylhydantoin during lactation?
Is it safe for a nursing mother and a child?

Type IB antiarrhythmic agent and anticonvulsant drug. It is excreted into breast milk in clinically non-significant amount and no problems have appeared on clinical follow up, and, long-term psychomotor development in infants whose mothers received this treatment, except in some isolated cases of patients who were on anticonvulsant polytherapy.Plasma levels in these infants were undetectable or very low. It may appear a withdrawal syndrome with hyperexcitability after abruptly stopping breastfeeding. It has been authorized for use in infants and newborns. American Academy of Pediatrics states that it is usually compatible with breastfeeding medication.WHO List of Essential Medicines 2002: compatible with breastfeeding.

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Types of risk

VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...

LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...

HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...

VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...

Scientific literature

The level of risk for breastfeeding is confirmed in these scientific publications:
  1. http://www.ncbi.nlm.nih.gov/pubmed/24934501
  2. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122685/pdf/nihms606090.pdf
  3. http://www.ncbi.nlm.nih.gov/pubmed/23985170
  4. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844381/pdf/1824-7288-39-50.pdf
  5. http://www.ncbi.nlm.nih.gov/pubmed/23178070
  6. http://www.ncbi.nlm.nih.gov/pubmed/21852881
  7. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152149/pdf/i1535-7511-11-4-116.pdf
  8. http://www.ncbi.nlm.nih.gov/pubmed/21106960
  9. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014232/pdf/8296.pdf
  10. http://www.ncbi.nlm.nih.gov/pubmed/23055906
  11. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460796/pdf/i1551-6776-14-4-212.pdf
  12. http://www.ncbi.nlm.nih.gov/pubmed/19398680
  13. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475193/pdf/znl142.pdf
  14. http://www.ncbi.nlm.nih.gov/pubmed/17044826
  15. http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2006.00660.x/epdf
  16. http://www.ncbi.nlm.nih.gov/pubmed/16932550
  17. http://www.nature.com/nrneurol/journal/v2/n4/pdf/ncpneuro0153.pdf
  18. http://www.ncbi.nlm.nih.gov/pubmed/16404803
  19. http://www.ncbi.nlm.nih.gov/pubmed/15879038
  20. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1743264/pdf/v081p00278.pdf
  21. http://www.ncbi.nlm.nih.gov/pubmed/15591613
  22. http://www.ncbi.nlm.nih.gov/pubmed/14504308
  23. http://whqlibdoc.who.int/hq/2002/55732.pdf
  24. http://www.ncbi.nlm.nih.gov/pubmed/11533352
  25. http://pediatrics.aappublications.org/content/108/3/776.full.pdf
  26. http://www.ncbi.nlm.nih.gov/pubmed/10877037
  27. http://www.ncbi.nlm.nih.gov/pubmed/10937463
  28. http://www.ncbi.nlm.nih.gov/pubmed/9682171
  29. http://www.ncbi.nlm.nih.gov/pubmed/3239295
  30. http://www.ncbi.nlm.nih.gov/pubmed/3983173
  31. http://www.ncbi.nlm.nih.gov/pubmed/6819105
  32. http://www.ncbi.nlm.nih.gov/pubmed/7157456
  33. http://www.ncbi.nlm.nih.gov/pubmed/7103792
  34. http://www.ncbi.nlm.nih.gov/pubmed/465285
  35. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1429673/pdf/brjclinpharm00239-0084.pdf
  36. http://www.ncbi.nlm.nih.gov/pubmed/4808742
  37. http://www.ncbi.nlm.nih.gov/pubmed/5539782
  38. http://www.ncbi.nlm.nih.gov/pubmed/13222209

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