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Recommendations made
pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.


woomen

Is it allowed to take Fluoxetine Hydrochloride during lactation?
Is it safe for a nursing mother and a child?

Higher excretion into breast milk than other related antidepressant drugs. The active metabolite called Norfluoxetine has a longer half-life (4 to 16 days). Like other antidepressant drugs may induce hyperprolactinemia and galactorrhea. Few cases of colicky pain, irritability, insomnia, anorexia and slow weight gain have been described. However, most reported cases have failed to show harm effect outside the newborn period. Large experience with the use of Fluoxatine did not find harm effect on weight gain and neurological development of infants either at short or long term. Most problems have appeared in the early neonatal period either in newborns or premature infants whose mothers were on Fluoxetine during pregnancy. Stop or switch to other medication either at some days before delivery or in the first month postpartum would be recommended. Same considerations should be done in case of prematurity, however, medication must be continued if necessary. Women on anti-depressant treatment are in need of stronger support because of higher risk of breastfeeding failure.

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woomen

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Types of risk

VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...

LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...

HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...

VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...

Scientific literature

The level of risk for breastfeeding is confirmed in these scientific publications:
  1. http://www.ncbi.nlm.nih.gov/pubmed/26204124
  2. https://abm.memberclicks.net/assets/DOCUMENTS/PROTOCOLS/18-use-of-antidepressants-protocol-english.pdf
  3. http://www.ncbi.nlm.nih.gov/pubmed/23260337
  4. http://www.ncbi.nlm.nih.gov/pubmed/23178070
  5. http://www.ncbi.nlm.nih.gov/pubmed/23979084
  6. http://pediatrics.aappublications.org/content/132/3/e796.full.pdf
  7. http://www.ncbi.nlm.nih.gov/pubmed/22283766
  8. http://www.ncbi.nlm.nih.gov/pubmed/22344850
  9. http://www.ncbi.nlm.nih.gov/pubmed/20958101
  10. http://www.ncbi.nlm.nih.gov/pubmed/22077504
  11. http://www.ncbi.nlm.nih.gov/pubmed/22299006
  12. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267169/pdf/CWHR-7-28.pdf
  13. http://www.ncbi.nlm.nih.gov/pubmed/22192462
  14. http://www.ncbi.nlm.nih.gov/pubmed/21894275
  15. http://www.racgp.org.au/download/documents/AFP/2011/September/201109amir.pdf
  16. http://www.ncbi.nlm.nih.gov/pubmed/20807106
  17. http://www.ncbi.nlm.nih.gov/pubmed/19661763
  18. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902256/pdf/nihms139489.pdf
  19. http://www.ncbi.nlm.nih.gov/pubmed/18272227
  20. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556848/pdf/nihms66029.pdf
  21. http://www.ncbi.nlm.nih.gov/pubmed/18333769
  22. http://online.liebertpub.com/doi/pdfplus/10.1089/bfm.2007.9978
  23. http://www.ncbi.nlm.nih.gov/pubmed/16848655
  24. http://www.ncbi.nlm.nih.gov/pubmed/15687451
  25. http://www.ncbi.nlm.nih.gov/pubmed/15691224
  26. http://www.ncbi.nlm.nih.gov/pubmed/15367050
  27. http://www.ncbi.nlm.nih.gov/pubmed/14749550
  28. http://www.ncbi.nlm.nih.gov/pubmed/15169695
  29. http://ajp.psychiatryonline.org/doi/pdf/10.1176/appi.ajp.161.6.1066
  30. http://www.ncbi.nlm.nih.gov/pubmed/15591613
  31. http://www.ncbi.nlm.nih.gov/pubmed/12709723
  32. http://www.ncbi.nlm.nih.gov/pubmed/12716242
  33. http://www.ncbi.nlm.nih.gov/pubmed/14595087
  34. http://www.ncbi.nlm.nih.gov/pubmed/14645327
  35. http://www.jabfm.org/content/16/5/372.full.pdf
  36. http://www.ncbi.nlm.nih.gov/pubmed/12242061
  37. http://www.ncbi.nlm.nih.gov/pubmed/12411224
  38. http://www.ncbi.nlm.nih.gov/pubmed/12124409
  39. http://www.ncbi.nlm.nih.gov/pubmed/11213313
  40. http://www.ncbi.nlm.nih.gov/pubmed/11354903
  41. http://www.ncbi.nlm.nih.gov/pubmed/11720696
  42. http://www.ncbi.nlm.nih.gov/pubmed/11475200
  43. http://tidsskriftet.no/article/248947
  44. http://www.ncbi.nlm.nih.gov/pubmed/11354903
  45. http://www.ncbi.nlm.nih.gov/pubmed/11332169
  46. http://www.ncbi.nlm.nih.gov/pubmed/11475200
  47. http://www.ncbi.nlm.nih.gov/pubmed/10390297
  48. http://pediatrics.aappublications.org/content/104/1/e11.full.pdf
  49. http://www.ncbi.nlm.nih.gov/pubmed/10545587
  50. http://www.ncbi.nlm.nih.gov/pubmed/10583022
  51. http://www.ncbi.nlm.nih.gov/pubmed/10485633
  52. http://www.ncbi.nlm.nih.gov/pubmed/9475699
  53. http://www.ncbi.nlm.nih.gov/pubmed/9519072
  54. http://www.ncbi.nlm.nih.gov/pubmed/9296322
  55. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2042834/pdf/bcp_0652.pdf
  56. http://www.ncbi.nlm.nih.gov/pubmed/9296327
  57. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2042842/pdf/bcp_0576.pdf
  58. http://www.ncbi.nlm.nih.gov/pubmed/9441422
  59. http://www.ncbi.nlm.nih.gov/pubmed/9247422
  60. http://ajp.psychiatryonline.org/doi/pdf/10.1176/ajp.154.8.1174a
  61. http://www.ncbi.nlm.nih.gov/pubmed/8780414
  62. http://www.ncbi.nlm.nih.gov/pubmed/8932542
  63. http://www.ncbi.nlm.nih.gov/pubmed/8973997
  64. http://www.ncbi.nlm.nih.gov/pubmed/8825840
  65. http://www.ncbi.nlm.nih.gov/pubmed/8282672
  66. http://www.ncbi.nlm.nih.gov/pubmed/1557252
  67. http://www.ncbi.nlm.nih.gov/pubmed/1764189
  68. http://www.ncbi.nlm.nih.gov/pubmed/2324084

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