Recommendations made
pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.
Is it allowed to take Glycyrrhizin during lactation? |
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Root of leguminous herb is used. Content: essential oil, flavonoids, tannins, saponins, hydroxi-coumarins.... Unproven effects: anti-ulcerative and expectorant. Indication after Commission E of German Ministry of Health: gastritis, gastric ulcer, cough, bronchitis. Because of mineralocorticoid effects, Pseudoaldosteronism, Hypokalemic palsy, Hypernatremia, Edema, Heart arrhythmias and Arterial Hypertension, a longstanding use or abuse of licorice may be a cause of severe health disorders. May be a cause of abortion and premature labor if taken while pregnancy. Since it has anti-prolactin and estrogenic effects, decrease of milk production can occur within the first weeks after birth. Reportedly, one case of hyperprolactinemia has occurred. There is no proof on its galactagogue effect. Glycyrrhizin is responsible of many effects of Licorice which is excreted in small amount into breast milk. Two infants younger than one months were severely intoxicated (lethargy) after their mothers had drunk an daily average of 2 liters of a beverage containing a mixture of Licorice, Fennel, Anise and Goat's rue. It was assumed to be related to anethol contained in the fennel and anise. |
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Types of risk
VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...
LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...
HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...
VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...
Scientific literature
The level of risk for breastfeeding is confirmed in these scientific publications:- http://www.ncbi.nlm.nih.gov/pubmed/25878948
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397262/pdf/40203_2015_Article_8.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/23703562
- http://www.ncbi.nlm.nih.gov/pubmed/24051150
- http://www.ncbi.nlm.nih.gov/pubmed/24303973
- https://thewomens.r.worldssl.net/images/uploads/fact-sheets/Herbal-traditional-medicines-in-breastfeeding.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/22220176
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246777/pdf/OGI2012-562704.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/23185686
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498851/pdf/10.1177_2042018812454322.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/21894275
- http://www.racgp.org.au/download/documents/AFP/2011/September/201109amir.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/20872924
- http://www.ncbi.nlm.nih.gov/pubmed/14672753
- http://www.ncbi.nlm.nih.gov/pubmed/12396997
- http://apps.who.int/medicinedocs/pdf/s2200e/s2200e.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/10474275
- http://www.ncbi.nlm.nih.gov/pubmed/9492350
- http://www.ncbi.nlm.nih.gov/pubmed/7919774
- http://www.ncbi.nlm.nih.gov/pubmed/6491873
- http://www.ncbi.nlm.nih.gov/pubmed/262485
- http://www.ncbi.nlm.nih.gov/pubmed/84965