Recommendations made
pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.
Is it allowed to take Granulocyte colony-stimulating factor (G-CSF) during lactation? |
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Non-glycosylated stimulating factor of granulocyte colonies (G-CSF) which is obtained by recombinant technology.The naturally occurring product is found in breast milk. A very high molecular weight explains the insignificant or no excretion into milk that has been observed both with Lenograstim and Filgrastim. Its low oral bioavailability hampers absorption into infant plasma from the breast milk ingested, as for their proteic nature it is degraded in the gastrointestinal tract, not being absorbed. Filgrastim is not absorbed by the infant's gut even during the neonatal period or prematurity. The granulocyte colony-stimulating factor has been used in premature newborns, both on prevention and treatment of neonatal sepsis and/or necrotizing enterocolitis without adverse effects being observed among treated infants. The bovine G-CSF is found in the usual diet of meat eaters. |
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Types of risk
VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...
LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...
HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...
VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...
Scientific literature
The level of risk for breastfeeding is confirmed in these scientific publications:- http://www.ncbi.nlm.nih.gov/pubmed/23199900
- http://www.ncbi.nlm.nih.gov/pubmed/23287427
- http://humupd.oxfordjournals.org/content/19/3/259.full.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/17914246
- http://www.karger.com/Article/Abstract/109267
- http://www.ncbi.nlm.nih.gov/pubmed/16769348
- http://www.ncbi.nlm.nih.gov/pubmed/15892086
- http://www.ncbi.nlm.nih.gov/pubmed/12897302
- http://www.ncbi.nlm.nih.gov/pubmed/12917944
- http://www.ncbi.nlm.nih.gov/pubmed/14663166
- http://www.karger.com/Article/Abstract/74226
- http://www.ncbi.nlm.nih.gov/pubmed/11320043
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1721238/pdf/v084p0F172.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/7520770
- http://www.bloodjournal.org/content/bloodjournal/84/5/1427.full.pdf