Recommendations made
pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.
Is it allowed to take Heparin Sodium during lactation? |
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The high molecular weight of both standard or non-fractionated Heparin, and, so-called low molecular weight Heparin makes excretion into breast milk extremely difficult. Dalteparin has been shown not to be excreted into breast milk . In addition, Heparins are inactivated in the GE tract where they are not absorbed which is reason to have a nil oral bioavailability. Absence of anti-clotting activity in breastfed infants has been shown after treatment of the mother with Enoxaparin. Risk of Heparin-induced Thrombocytopenia or Osteoporosis in the mother is lower with low weight Heparins. Eleventh WHO Model List of Essential Drugs 2002: Compatible with breastfeeding. |
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Would you like to ask something else about Heparin Sodium ? |
Types of risk
VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...
LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...
HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...
VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...
Scientific literature
The level of risk for breastfeeding is confirmed in these scientific publications:- http://www.ncbi.nlm.nih.gov/pubmed/25138263
- http://www.ncbi.nlm.nih.gov/pubmed/23702122
- http://www.ncbi.nlm.nih.gov/pubmed/23178070
- http://www.ncbi.nlm.nih.gov/pubmed/23094528
- http://www.turkishjournalpediatrics.org/pediatrics/pdf/pdf_TJP_1052.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/21921048
- http://www.bloodjournal.org/content/bloodjournal/118/20/5394.full.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/21207321
- http://www.ncbi.nlm.nih.gov/pubmed/12420239
- http://www.ncbi.nlm.nih.gov/pubmed/12422463
- http://whqlibdoc.who.int/hq/2002/55732.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/11736885
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2014571/pdf/bcp0052-0708.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/10841132
- http://www.ncbi.nlm.nih.gov/pubmed/10724046
- http://archinte.jamanetwork.com/data/Journals/INTEMED/11959/ira90005.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/9488787
- http://www.ncbi.nlm.nih.gov/pubmed/8763733
- http://www.ncbi.nlm.nih.gov/pubmed/1505142
- http://www.ncbi.nlm.nih.gov/pubmed/2311907
- http://www.ncbi.nlm.nih.gov/pubmed/3069439
- http://www.ncbi.nlm.nih.gov/pubmed/3569823
- http://www.ncbi.nlm.nih.gov/pubmed/6993082
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