Recommendations made
pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.
Is it allowed to take Hyoscine Butylbromide during lactation? |
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Scopolamine or Hyoscine is a alcaloid which is naturally found in several plants among Solanacea family. With a similar chemical structure of Atropine, it shows anti-muscarinic and anti-cholinergic effects (decrease in saliva, bronchial, sweat and gastric secretion, tachycardia, pupil dilation, anti-spasmodic effect on the intestine and urinary tract) Most frequently used formulations contain buthylbromurate, methybromurate and hydrobromurate. Skin patches contain purified Scopolamine. Used for prevention of motion-sickness of the traveler and treatment of nausea, post-anesthesia vomiting. Also, as anti-spasmodict and treatment of ophthalmologic disorders. At latest update, relevant published data on excretion into breast milk were not found. Due to a low oral bioavailability that minimizes the presence into the infant's plasma from mother's milk ingested, thus, the expert consensus is that the risk of use while breastfeeding is minimal. (American Academy of Pediatrics - 2013 says that is usually compatible with breastfeeding) Since at small dosage Scopolamine poisoning with alarming symptoms may occur (irritability, delirium, redness of skin, mouth dryness, constipation, urine retention), we would recommend a cautious and moderate use with a dose as low as possible with a delay of at least 3 hours for breastfeeding after medication. Avoid use if the infant is younger than 2 months or premature. |
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Would you like to ask something else about Hyoscine Butylbromide ? |
Types of risk
VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...
LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...
HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...
VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...
Scientific literature
The level of risk for breastfeeding is confirmed in these scientific publications:- https://abm.memberclicks.net/assets/DOCUMENTS/PROTOCOLS/15-analgesia-and-anesthesia-protocol-english.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/20074099
- http://jtm.oxfordjournals.org/content/jtm/17/1/32.full.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/11533352
- http://pediatrics.aappublications.org/content/108/3/776.full.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/9725548
- http://www.ncbi.nlm.nih.gov/pubmed/8346780
- http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2044.1993.tb07130.x/epdf
- http://www.ncbi.nlm.nih.gov/pubmed/2193993
- http://www.ncbi.nlm.nih.gov/pubmed/2762223