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Recommendations made
pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.


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Is it allowed to take Metronidazole Vaginal Gel during lactation?
Is it safe for a nursing mother and a child?

Used for treatment of acne (Gel) and vaginitis (Gel, Ovules) Significant levels in breast milk are unlikely because of low content of Metronidazole in products for topical use (less than 1%) and low absorption by vaginal mucosa (Ovules: 25%, Gel: 56%). Through skin it is not absorbed at all. Like most medications for topical use, a poor absorption make it compatible with breastfeeding. Widely used for treatment of Giardia lamblia infections, even in small infants, without adverse effects reported. Metronidazole may produce a red discoloration of corporal fluids and bitter flavor of the milk with no harm effect on the child.

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Types of risk

VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...

LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...

HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...

VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...

Scientific literature

The level of risk for breastfeeding is confirmed in these scientific publications:
  1. http://www.ncbi.nlm.nih.gov/pubmed/23657872
  2. http://www.ncbi.nlm.nih.gov/pubmed/23914887
  3. http://www.ncbi.nlm.nih.gov/pubmed/23178070
  4. http://www.ncbi.nlm.nih.gov/pubmed/23749699
  5. http://medwiekurozwoj.pl/articles/2013-1-10.pdf
  6. http://www.ncbi.nlm.nih.gov/pubmed/21160459
  7. http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5912a1.htm
  8. http://www.ncbi.nlm.nih.gov/pubmed/21172284
  9. http://download.journals.elsevierhealth.com/pdfs/journals/1873-9946/PIIS1873994609000269.pdf
  10. http://www.ncbi.nlm.nih.gov/pubmed/19585498
  11. http://www.ncbi.nlm.nih.gov/pubmed/17923223
  12. http://www.ncbi.nlm.nih.gov/pubmed/14583068
  13. http://www.ncbi.nlm.nih.gov/pubmed/14623482
  14. http://whqlibdoc.who.int/hq/2002/55732.pdf
  15. http://www.ncbi.nlm.nih.gov/pubmed/12431134
  16. http://www.ncbi.nlm.nih.gov/pubmed/11847854
  17. http://www.ncbi.nlm.nih.gov/pubmed/10845129
  18. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2144878/pdf/canfamphys00027-0067.pdf
  19. http://www.ncbi.nlm.nih.gov/pubmed/9502459
  20. http://www.ncbi.nlm.nih.gov/pubmed/9596854
  21. http://www.ncbi.nlm.nih.gov/pubmed/9465933
  22. http://www.ncbi.nlm.nih.gov/pubmed/1288560
  23. http://www.ncbi.nlm.nih.gov/pubmed/3203060
  24. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1386498/pdf/brjclinpharm00097-0046.pdf
  25. http://www.ncbi.nlm.nih.gov/pubmed/3099894
  26. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1342181/pdf/bmjcred00263-0029.pdf
  27. http://www.ncbi.nlm.nih.gov/pubmed/3865353
  28. http://www.ncbi.nlm.nih.gov/pubmed/6854509
  29. http://www.ncbi.nlm.nih.gov/pubmed/7200704
  30. http://www.ncbi.nlm.nih.gov/pubmed/6941457
  31. http://www.ncbi.nlm.nih.gov/pubmed/7454176
  32. http://www.ncbi.nlm.nih.gov/pubmed/6934434
  33. http://www.ncbi.nlm.nih.gov/pubmed/357408
  34. http://www.ncbi.nlm.nih.gov/pubmed/13901320
  35. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1047447/pdf/brjvendis00126-0040.pdf

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