Recommendations made
pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.
Is it allowed to take Org-9426 during lactation? |
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It is a non-depolarizing muscle relaxant drug with a peripheral action that is used as premedication for endotracheal intubation, general anesthesia and mechanical ventilation. Breastfed infants have not shown any problem after 1.5 to 5 hours of anesthesia time period with Rocuronio (additional drugs like Propofol, Remifentanil and Xenon were used). A high molecular weight may decrease excretion into breast milk as well as a rapid elimination time. In addition, a low oral bioavailability makes unlikely a pass from ingested mother's milk onto the infant's plasma. Rocuronium should not prevent a mother from breast feeding her baby shortly after recovering from an anesthesia if she is in good condition. |
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Would you like to ask something else about Org-9426 ? |
Types of risk
VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...
LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...
HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...
VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...
Scientific literature
The level of risk for breastfeeding is confirmed in these scientific publications:- http://www.ncbi.nlm.nih.gov/pubmed/24372776
- http://www.ncbi.nlm.nih.gov/pubmed/20167123
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837001/pdf/1471-2253-10-1.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/17541461
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1595306/pdf/JPE150050.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/8171959