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Recommendations made
pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.


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Is it allowed to take Pyridoxamine Hydrochloride during lactation?
Is it safe for a nursing mother and a child?

Concentration of vitamin B6 in the breast milk is directly related to the amount present in diet with the possibility of a high increment by an excessive consumption through the diet. Daily allowance of vitamin B6 ranges from 2 to 3 mg. A balanced and varied diet is enough without a need for extra supplementation with this vitamin. Vitamin B6 deficiency is extremely rare since it is widely distributed in many foods. In those cases where supplementation is required, it is recommended not to exceed 40 mg a-day. There are controversial data on the capacity of a high dose of Pyridoxine to inhibit the secretion of Prolactin and suppress the milk production. The American Academy of Pediatrics rates it as usually compatible with breastfeeding.

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Types of risk

VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...

LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...

HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...

VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...

Scientific literature

The level of risk for breastfeeding is confirmed in these scientific publications:
  1. http://www.ncbi.nlm.nih.gov/pubmed/25591052
  2. http://www.ncbi.nlm.nih.gov/pubmed/26186707
  3. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505892/pdf/pone.0133285.pdf
  4. http://www.ncbi.nlm.nih.gov/pubmed/26383056
  5. http://www.elsevier.es/en/linksolver/ft/pii/S1695-4033(15)00305-7
  6. http://www.ncbi.nlm.nih.gov/pubmed/24890188
  7. http://www.ncbi.nlm.nih.gov/pubmed/23690784
  8. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649700/pdf/OGI2013-752980.pdf
  9. http://www.ncbi.nlm.nih.gov/pubmed/22972088
  10. http://www.ncbi.nlm.nih.gov/pubmed/22296250
  11. http://onlinelibrary.wiley.com/doi/10.1111/j.1740-8709.2010.00276.x/epdf
  12. http://www.ncbi.nlm.nih.gov/pubmed/15817867
  13. http://ajcn.nutrition.org/content/81/4/880.full.pdf
  14. http://whqlibdoc.who.int/hq/2002/55732.pdf
  15. http://www.ncbi.nlm.nih.gov/pubmed/12026182
  16. http://www.ncbi.nlm.nih.gov/pubmed/12396161
  17. http://www.ncbi.nlm.nih.gov/pubmed/11533352
  18. http://pediatrics.aappublications.org/content/108/3/776.full.pdf
  19. http://www.ncbi.nlm.nih.gov/pubmed/11339161
  20. http://www.ncbi.nlm.nih.gov/pubmed/2333841
  21. http://www.ncbi.nlm.nih.gov/pubmed/2345263
  22. http://www.ncbi.nlm.nih.gov/pubmed/2074350
  23. http://www.ncbi.nlm.nih.gov/pubmed/3941618
  24. http://www.ncbi.nlm.nih.gov/pubmed/3728001
  25. http://www.ncbi.nlm.nih.gov/pubmed/4058985
  26. http://www.ncbi.nlm.nih.gov/pubmed/7148607
  27. http://www.ncbi.nlm.nih.gov/pubmed/7424809
  28. http://www.ncbi.nlm.nih.gov/pubmed/7020052
  29. http://www.ncbi.nlm.nih.gov/pubmed/569255
  30. http://www.ncbi.nlm.nih.gov/pubmed/474683
  31. http://www.ncbi.nlm.nih.gov/pubmed/653534
  32. http://www.ncbi.nlm.nih.gov/pubmed/580517
  33. http://www.ncbi.nlm.nih.gov/pubmed/766822
  34. http://www.ncbi.nlm.nih.gov/pubmed/1268149
  35. http://www.ncbi.nlm.nih.gov/pubmed/945301
  36. http://www.ncbi.nlm.nih.gov/pubmed/1209435
  37. http://www.ncbi.nlm.nih.gov/pubmed/4579974

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