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pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.


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Is it allowed to take Valproate Semisodium during lactation?
Is it safe for a nursing mother and a child?

It is excreted in breast milk in clinically non-significant amount without problems in the short or long term in infants whose mothers were treated. Plasma levels of these infants were undetectable or very low. Cognitive development did not suffer any alteration. An infant was presented with thrombocytopenic purpura and anemia who recovered after removing valproate in the mother. However, doubts were raised on whether it was instead a post-viral reaction that led to idiopathic thrombocytopenic purpura. The administration of valproic acid does not affect prolactin levels. The American Academy of Pediatrics rates it as usual compatible with breastfeeding medication.WHO List of Essential Medicines 2002: compatible with breastfeeding.

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Types of risk

VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...

LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...

HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...

VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...

Scientific literature

The level of risk for breastfeeding is confirmed in these scientific publications:
  1. http://www.ncbi.nlm.nih.gov/pubmed/26330649
  2. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539876/
  3. http://www.ncbi.nlm.nih.gov/pubmed/26344706
  4. http://www.ncbi.nlm.nih.gov/pubmed/24934501
  5. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122685/pdf/nihms606090.pdf
  6. http://www.ncbi.nlm.nih.gov/pubmed/25217187
  7. http://www.ncbi.nlm.nih.gov/pubmed/23985170
  8. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844381/pdf/1824-7288-39-50.pdf
  9. http://www.ncbi.nlm.nih.gov/pubmed/23178070
  10. http://www.ncbi.nlm.nih.gov/pubmed/24061295
  11. http://archneur.jamanetwork.com/data/Journals/NEUR/928523/noi130062.pdf
  12. http://www.ncbi.nlm.nih.gov/pubmed/22683887
  13. http://www.ncbi.nlm.nih.gov/pubmed/22770820
  14. http://www.seizure-journal.com/article/S1059-1311(12)00157-4/pdf
  15. http://www.ncbi.nlm.nih.gov/pubmed/22787503
  16. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394379/pdf/Dtsch_Arztebl_Int-109-0419.pdf
  17. http://www.ncbi.nlm.nih.gov/pubmed/21852881
  18. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152149/pdf/i1535-7511-11-4-116.pdf
  19. http://onlinelibrary.wiley.com/doi/10.1111/j.1742-7843.2011.00722.x/abstract
  20. http://onlinelibrary.wiley.com/doi/10.1111/j.1742-7843.2011.00722.x/epdf
  21. http://www.ncbi.nlm.nih.gov/pubmed/21267028
  22. http://tidsskriftet.no/pdf/pdf2011/126-9.pdf
  23. http://www.ncbi.nlm.nih.gov/pubmed/21106960
  24. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014232/pdf/8296.pdf
  25. http://www.ncbi.nlm.nih.gov/pubmed/23055906
  26. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460796/pdf/i1551-6776-14-4-212.pdf
  27. http://www.ncbi.nlm.nih.gov/pubmed/19398680
  28. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475193/pdf/znl142.pdf
  29. http://www.ncbi.nlm.nih.gov/pubmed/19884236
  30. http://ajp.psychiatryonline.org/doi/pdf/10.1176/appi.ajp.2009.08121902
  31. http://www.ncbi.nlm.nih.gov/pubmed/17764381
  32. http://www.ncbi.nlm.nih.gov/pubmed/17044826
  33. http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2006.00660.x/epdf
  34. http://www.ncbi.nlm.nih.gov/pubmed/16932550
  35. http://www.nature.com/nrneurol/journal/v2/n4/pdf/ncpneuro0153.pdf
  36. http://www.ncbi.nlm.nih.gov/pubmed/16910623
  37. http://www.ncbi.nlm.nih.gov/pubmed/15857447
  38. http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2005.54804.x/epdf
  39. http://www.ncbi.nlm.nih.gov/pubmed/16404803
  40. http://www.ncbi.nlm.nih.gov/pubmed/15879038
  41. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1743264/pdf/v081p00278.pdf
  42. http://www.ncbi.nlm.nih.gov/pubmed/15591613
  43. http://www.ncbi.nlm.nih.gov/pubmed/14504308
  44. http://whqlibdoc.who.int/hq/2002/55732.pdf
  45. http://www.ncbi.nlm.nih.gov/pubmed/11533352
  46. http://pediatrics.aappublications.org/content/108/3/776.full.pdf
  47. http://www.ncbi.nlm.nih.gov/pubmed/11527233
  48. http://www.ncbi.nlm.nih.gov/pubmed/10877037
  49. http://www.ncbi.nlm.nih.gov/pubmed/10732654
  50. http://www.ncbi.nlm.nih.gov/pubmed/10937463
  51. http://www.ncbi.nlm.nih.gov/pubmed/10817100
  52. http://www.ncbi.nlm.nih.gov/pubmed/10840214
  53. http://www.ncbi.nlm.nih.gov/pubmed/10390297
  54. http://pediatrics.aappublications.org/content/104/1/e11.full.pdf
  55. http://www.ncbi.nlm.nih.gov/pubmed/10084341
  56. http://www.ncbi.nlm.nih.gov/pubmed/9555601
  57. http://www.ncbi.nlm.nih.gov/pubmed/9732101
  58. http://www.ncbi.nlm.nih.gov/pubmed/9202628
  59. http://www.ncbi.nlm.nih.gov/pubmed/1525801
  60. http://www.ncbi.nlm.nih.gov/pubmed/3239295
  61. http://www.ncbi.nlm.nih.gov/pubmed/3135429
  62. http://www.ncbi.nlm.nih.gov/pubmed/3936331
  63. http://www.ncbi.nlm.nih.gov/pubmed/6438834
  64. http://www.ncbi.nlm.nih.gov/pubmed/6819105
  65. http://www.ncbi.nlm.nih.gov/pubmed/6795343
  66. http://www.ncbi.nlm.nih.gov/pubmed/373647
  67. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1545236/pdf/archdisch00795-0074a.pdf

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