Recommendations made
pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.
Is it allowed to take Valproate Semisodium during lactation? |
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It is excreted in breast milk in clinically non-significant amount without problems in the short or long term in infants whose mothers were treated. Plasma levels of these infants were undetectable or very low. Cognitive development did not suffer any alteration. An infant was presented with thrombocytopenic purpura and anemia who recovered after removing valproate in the mother. However, doubts were raised on whether it was instead a post-viral reaction that led to idiopathic thrombocytopenic purpura. The administration of valproic acid does not affect prolactin levels. The American Academy of Pediatrics rates it as usual compatible with breastfeeding medication.WHO List of Essential Medicines 2002: compatible with breastfeeding. |
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Would you like to ask something else about Valproate Semisodium ? |
Types of risk
VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...
LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...
HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...
VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...
Scientific literature
The level of risk for breastfeeding is confirmed in these scientific publications:- http://www.ncbi.nlm.nih.gov/pubmed/26330649
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539876/
- http://www.ncbi.nlm.nih.gov/pubmed/26344706
- http://www.ncbi.nlm.nih.gov/pubmed/24934501
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122685/pdf/nihms606090.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/25217187
- http://www.ncbi.nlm.nih.gov/pubmed/23985170
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844381/pdf/1824-7288-39-50.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/23178070
- http://www.ncbi.nlm.nih.gov/pubmed/24061295
- http://archneur.jamanetwork.com/data/Journals/NEUR/928523/noi130062.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/22683887
- http://www.ncbi.nlm.nih.gov/pubmed/22770820
- http://www.seizure-journal.com/article/S1059-1311(12)00157-4/pdf
- http://www.ncbi.nlm.nih.gov/pubmed/22787503
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394379/pdf/Dtsch_Arztebl_Int-109-0419.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/21852881
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152149/pdf/i1535-7511-11-4-116.pdf
- http://onlinelibrary.wiley.com/doi/10.1111/j.1742-7843.2011.00722.x/abstract
- http://onlinelibrary.wiley.com/doi/10.1111/j.1742-7843.2011.00722.x/epdf
- http://www.ncbi.nlm.nih.gov/pubmed/21267028
- http://tidsskriftet.no/pdf/pdf2011/126-9.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/21106960
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014232/pdf/8296.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/23055906
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460796/pdf/i1551-6776-14-4-212.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/19398680
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475193/pdf/znl142.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/19884236
- http://ajp.psychiatryonline.org/doi/pdf/10.1176/appi.ajp.2009.08121902
- http://www.ncbi.nlm.nih.gov/pubmed/17764381
- http://www.ncbi.nlm.nih.gov/pubmed/17044826
- http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2006.00660.x/epdf
- http://www.ncbi.nlm.nih.gov/pubmed/16932550
- http://www.nature.com/nrneurol/journal/v2/n4/pdf/ncpneuro0153.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/16910623
- http://www.ncbi.nlm.nih.gov/pubmed/15857447
- http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2005.54804.x/epdf
- http://www.ncbi.nlm.nih.gov/pubmed/16404803
- http://www.ncbi.nlm.nih.gov/pubmed/15879038
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1743264/pdf/v081p00278.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/15591613
- http://www.ncbi.nlm.nih.gov/pubmed/14504308
- http://whqlibdoc.who.int/hq/2002/55732.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/11533352
- http://pediatrics.aappublications.org/content/108/3/776.full.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/11527233
- http://www.ncbi.nlm.nih.gov/pubmed/10877037
- http://www.ncbi.nlm.nih.gov/pubmed/10732654
- http://www.ncbi.nlm.nih.gov/pubmed/10937463
- http://www.ncbi.nlm.nih.gov/pubmed/10817100
- http://www.ncbi.nlm.nih.gov/pubmed/10840214
- http://www.ncbi.nlm.nih.gov/pubmed/10390297
- http://pediatrics.aappublications.org/content/104/1/e11.full.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/10084341
- http://www.ncbi.nlm.nih.gov/pubmed/9555601
- http://www.ncbi.nlm.nih.gov/pubmed/9732101
- http://www.ncbi.nlm.nih.gov/pubmed/9202628
- http://www.ncbi.nlm.nih.gov/pubmed/1525801
- http://www.ncbi.nlm.nih.gov/pubmed/3239295
- http://www.ncbi.nlm.nih.gov/pubmed/3135429
- http://www.ncbi.nlm.nih.gov/pubmed/3936331
- http://www.ncbi.nlm.nih.gov/pubmed/6438834
- http://www.ncbi.nlm.nih.gov/pubmed/6819105
- http://www.ncbi.nlm.nih.gov/pubmed/6795343
- http://www.ncbi.nlm.nih.gov/pubmed/373647
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1545236/pdf/archdisch00795-0074a.pdf