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Recommendations made
pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.


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Is it allowed to take Piperidolate Hydrochloride during lactation?
Is it safe for a nursing mother and a child?

t is a tertiary amine with antimuscarinic/anticholinergic effects, with an action similar to atropine. It has smooth muscle antispasmodic properties. Administered for gastroenteritis, duodenal ulcer, biliary conditions, dysmenorrhea and treatment of miscarriage and premature birth (Kyorin 2013, Sanofi 2010). Since the last update we have not found published data on its excretion in breast milk. There is hardly any published scientific data on this product: there are only 6 studies and the most recent dates from 1977. There is no pharmacokinetic data except that it has good absorption in the digestive tract (Sanofi 2010). Other anticholinergics from the same family such as tolterodine have high protein binding, which would make it unlikely that it passes into milk in significant amounts. Atropine in isolated doses is considered compatible with breastfeeding. During breastfeeding it may be prudent to avoid or take short-term and minimal doses, monitoring milk production as anticholinergics may reduce milk production (De Martino 1980, Bizarro 1980), especially the first few weeks postpartum. It is also advisable to monitor anticholinergic symptoms in the infant (dry mouth, constipation ..). See below the information of these related products:

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Types of risk

VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...

LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...

HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...

VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...

Trade Names

The main trade names in different countries containing in its composition Piperidolate Hydrochloride:

Scientific literature

The level of risk for breastfeeding is confirmed in these scientific publications:
  1. http://www.ncbi.nlm.nih.gov/pubmed/6788407
  2. http://www.ncbi.nlm.nih.gov/pubmed/6778491

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