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Is it allowed to take Phenytoin during lactation? |
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Type IB antiarrhythmic agent and anticonvulsant drug. It is excreted into breast milk in clinically non-significant amount and no problems have appeared on clinical follow up, and, long-term psychomotor development in infants whose mothers received this treatment, except in some isolated cases of patients who were on anticonvulsant polytherapy.Plasma levels in these infants were undetectable or very low. It may appear a withdrawal syndrome with hyperexcitability after abruptly stopping breastfeeding. It has been authorized for use in infants and newborns. American Academy of Pediatrics states that it is usually compatible with breastfeeding medication.WHO List of Essential Medicines 2002: compatible with breastfeeding. |
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Types of risk
VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...
LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...
HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...
VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...
Synonyms
Trade Names
The main trade names in different countries containing in its composition Phenytoin:Scientific literature
The level of risk for breastfeeding is confirmed in these scientific publications:- http://www.ncbi.nlm.nih.gov/pubmed/24934501
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122685/pdf/nihms606090.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/23985170
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844381/pdf/1824-7288-39-50.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/23178070
- http://www.ncbi.nlm.nih.gov/pubmed/21852881
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152149/pdf/i1535-7511-11-4-116.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/21106960
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014232/pdf/8296.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/23055906
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460796/pdf/i1551-6776-14-4-212.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/19398680
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475193/pdf/znl142.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/17044826
- http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2006.00660.x/epdf
- http://www.ncbi.nlm.nih.gov/pubmed/16932550
- http://www.nature.com/nrneurol/journal/v2/n4/pdf/ncpneuro0153.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/16404803
- http://www.ncbi.nlm.nih.gov/pubmed/15879038
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1743264/pdf/v081p00278.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/15591613
- http://www.ncbi.nlm.nih.gov/pubmed/14504308
- http://whqlibdoc.who.int/hq/2002/55732.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/11533352
- http://pediatrics.aappublications.org/content/108/3/776.full.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/10877037
- http://www.ncbi.nlm.nih.gov/pubmed/10937463
- http://www.ncbi.nlm.nih.gov/pubmed/9682171
- http://www.ncbi.nlm.nih.gov/pubmed/3239295
- http://www.ncbi.nlm.nih.gov/pubmed/3983173
- http://www.ncbi.nlm.nih.gov/pubmed/6819105
- http://www.ncbi.nlm.nih.gov/pubmed/7157456
- http://www.ncbi.nlm.nih.gov/pubmed/7103792
- http://www.ncbi.nlm.nih.gov/pubmed/465285
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1429673/pdf/brjclinpharm00239-0084.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/4808742
- http://www.ncbi.nlm.nih.gov/pubmed/5539782
- http://www.ncbi.nlm.nih.gov/pubmed/13222209
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