Recommendations made
pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.
Is it allowed to take Emtricitabine during lactation? |
|
Nucleoside and nucleotide analog reverse-transcriptase inhibitors (NRTI) (Ribera 2011). It is excreted in breast milk in small quantities (Mugwanya 2016, Benaboud 2011), much lower (200 times less) than the dose used in newborns and infants (Mugwanya 2016). The dosage in infants older than 3 months is 6 mg/kg/day and half from birth to that age (Ribera 2011). No problems have been observed in infants whose mothers were taking it, except for mild diarrhea in 4% of cases (Mugwanya 2016), so its use in breastfeeding mothers is considered safe for both HIV treatment and pre-exposure prophylaxis (Mugwanya 2017, Seidman 2017). The WHO recommends the so-called B+ option (highly active antiretroviral therapy - HAART) for all pregnant or breastfeeding women diagnosed with HIV, irrespective of their clinical status and CD4 count, continuing during breastfeeding and without interruption for life. Breastfeeding should be exclusive for 6 months and continue for 12 to 24 months along with complementary feeding (WHO 2016). The recommended HAART combination is tenofovir + lamivudine or emtricitabine + efavirenz daily.The infant, irrespective of the type of breastfeeding, should take nevirapine or zidovudine daily for 6 weeks (WHO 2016). Most countries in the world have adopted these recommendations which date from 2013 (Nelson 2014). |
|
Would you like to ask something else about Emtricitabine ? |
Types of risk
VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...
LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...
HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...
VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...
Trade Names
The main trade names in different countries containing in its composition Emtricitabine:Scientific literature
The level of risk for breastfeeding is confirmed in these scientific publications:- http://www.ncbi.nlm.nih.gov/pubmed/28361503
- http://www.ncbi.nlm.nih.gov/pubmed/28571500
- http://www.tandfonline.com/doi/full/10.1080/14740338.2017.1338271?scroll=top&needAccess=true
- http://www.ncbi.nlm.nih.gov/pubmed/27676257
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038971/pdf/pmed.1002132.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/27466667
- https://www.ncbi.nlm.nih.gov/books/NBK374294/pdf/Bookshelf_NBK374294.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/27583316
- https://www.ncbi.nlm.nih.gov/books/NBK379872/pdf/Bookshelf_NBK379872.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/24849481
- http://www.ncbi.nlm.nih.gov/pubmed/21531048
- http://www.ncbi.nlm.nih.gov/pubmed/21173182
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3067089/pdf/0514-10.pdf