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Recommendations made
pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.


woomen

Is it allowed to take Adenosylcobalamin during lactation?
Is it safe for a nursing mother and a child?

Vitamin B12 exists naturally in milk at a concentration of 1 nanogram / mL (range: 0.3 to 3 ng / mL). Maternal supplementation with cyanocobalamin barely increases milk levels in well-nourished women (Sandberg 1981), but it does improve the levels in women of low socioeconomic status (Sneed 1981). The concentration in colostrum is up to 28 times higher than that of mature milk.The daily requirements for Vitamin B12 are 2.4 micrograms and increase to 2.8 micrograms daily during breastfeeding. Foods rich in vitamin B12 are meat, offal, eggs, dairy products, salmon, sardines, clams and fortified cereals. With a varied and balanced diet no vitamin supplements are needed, but B12 deficiency has been observed in the plasma and milk of women with strict vegetarian diets (vegans), malabsorptive diseases (eg, Crohn's disease, celiac disease), bariatric surgery, poor nutritional status, pernicious anemia, low socio-economic status and in cases of natural disasters or wars. There are numerous publications showing that infants of these mothers are at high risk of disease due to vitamin B12 deficiency, which can lead to anemia, stunting and psychomotor retardation. "Flash pasteurization" applied to breast milk of mothers who are HIV+ does not decrease vitamin B12 concentration. American Academy of Pediatrics: medication usually compatible with breastfeeding (AAP 2001).

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woomen

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Types of risk

VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...

LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...

HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...

VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...

Scientific literature

The level of risk for breastfeeding is confirmed in these scientific publications:
  1. http://www.ncbi.nlm.nih.gov/pubmed/25591052
  2. http://www.ncbi.nlm.nih.gov/pubmed/26861098
  3. http://www.ncbi.nlm.nih.gov/pubmed/26887903
  4. http://www.ncbi.nlm.nih.gov/pubmed/26383056
  5. http://www.elsevier.es/en/linksolver/ft/pii/S1695-4033(15)00305-7
  6. http://www.ncbi.nlm.nih.gov/pubmed/24453156
  7. http://www.ncbi.nlm.nih.gov/pubmed/25840526
  8. http://www.ncbi.nlm.nih.gov/pubmed/25995278
  9. http://www.ncbi.nlm.nih.gov/pubmed/24598885
  10. http://www.ncbi.nlm.nih.gov/pubmed/24781684
  11. http://www.ncbi.nlm.nih.gov/pubmed/25076673
  12. http://www.ncbi.nlm.nih.gov/pubmed/25516326
  13. http://www.ncbi.nlm.nih.gov/pubmed/23883688
  14. https://www.jstage.jst.go.jp/article/jnsv/59/3/59_178/_pdf
  15. http://www.ncbi.nlm.nih.gov/pubmed/23781950
  16. http://www.ncbi.nlm.nih.gov/pubmed/23964388
  17. http://www.ncbi.nlm.nih.gov/pubmed/21947220
  18. http://www.ncbi.nlm.nih.gov/pubmed/22711730
  19. http://www.ncbi.nlm.nih.gov/pubmed/22726312
  20. http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2011.03207.x/epdf
  21. http://www.ncbi.nlm.nih.gov/pubmed/22696751
  22. http://www.ncbi.nlm.nih.gov/pubmed/22296250
  23. http://onlinelibrary.wiley.com/doi/10.1111/j.1740-8709.2010.00276.x/epdf
  24. http://www.ncbi.nlm.nih.gov/pubmed/20089427
  25. http://www.ncbi.nlm.nih.gov/pubmed/19710657
  26. http://www.ncbi.nlm.nih.gov/pubmed/19748244
  27. http://www.ncbi.nlm.nih.gov/pubmed/19852900
  28. http://www.ncbi.nlm.nih.gov/pubmed/20051934
  29. http://www.ncbi.nlm.nih.gov/pubmed/18614920
  30. http://www.ncbi.nlm.nih.gov/pubmed/18484483
  31. http://www.ncbi.nlm.nih.gov/pubmed/17230074
  32. http://www.ncbi.nlm.nih.gov/pubmed/17729202
  33. http://www.ncbi.nlm.nih.gov/pubmed/16189550
  34. http://www.ncbi.nlm.nih.gov/pubmed/15817867
  35. http://ajcn.nutrition.org/content/81/4/880.full.pdf
  36. http://www.ncbi.nlm.nih.gov/pubmed/15645284
  37. http://www.ncbi.nlm.nih.gov/pubmed/15982440
  38. http://www.ncbi.nlm.nih.gov/pubmed/16208206
  39. http://www.ncbi.nlm.nih.gov/pubmed/16310594
  40. http://www.ncbi.nlm.nih.gov/pubmed/15087959
  41. http://www.ncbi.nlm.nih.gov/pubmed/12578322
  42. http://www.ncbi.nlm.nih.gov/pubmed/11533352
  43. http://pediatrics.aappublications.org/content/108/3/776.full.pdf
  44. http://www.ncbi.nlm.nih.gov/pubmed/9311952
  45. http://www.ncbi.nlm.nih.gov/pubmed/7572725
  46. http://www.ncbi.nlm.nih.gov/pubmed/8442642
  47. http://www.ncbi.nlm.nih.gov/pubmed/2239784
  48. http://www.ncbi.nlm.nih.gov/pubmed/3415328
  49. http://www.ncbi.nlm.nih.gov/pubmed/3565293
  50. http://www.ncbi.nlm.nih.gov/pubmed/3728001
  51. http://www.ncbi.nlm.nih.gov/pubmed/3948463
  52. http://www.ncbi.nlm.nih.gov/pubmed/7258124
  53. http://www.ncbi.nlm.nih.gov/pubmed/7282599
  54. http://www.ncbi.nlm.nih.gov/pubmed/7424809
  55. http://www.ncbi.nlm.nih.gov/pubmed/7368919
  56. http://www.ncbi.nlm.nih.gov/pubmed/13864166

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