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pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.


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Is it allowed to take Methylprednisolone Sodium Succinate during lactation?
Is it safe for a nursing mother and a child?

Excreted into breast milk in non-significant amount with no problems reported in breastfed infants whose mothers were treated at a daily dose as high as 8 mg for a long time period. On long term treatments it would be advisable to wait for 2 - 4 hours until the next nurse to minimize the transfer of drug to breast milk. By waiting for 2 a 4 hours after a methylprednisolone megadose or a pulse therapy dose, the transfer into breast milk may be minimized as well. At high doses, intra-articular treatment with other steroid drugs (Triamcinolone) have transiently affected milk production. Steroids administered before delivery may delay initiation of phase II of Lactogenesis ("milk come in") and decrease milk production in the first postpartum week. Decreased production has been seen while taking Dexametasone. Steroid drugs are commonly used for Pediatric treatment with no side effects when infrequently used and for short-time periods. The American Academy of Pediatrics rates it compatible with breastfeeding. WHO Model List of Essential Medicines (2002) rates it compatible with breastfeeding

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Types of risk

VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...

LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...

HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...

VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...

Scientific literature

The level of risk for breastfeeding is confirmed in these scientific publications:
  1. http://www.ncbi.nlm.nih.gov/pubmed/26755401
  2. http://www.ncbi.nlm.nih.gov/pubmed/26966579
  3. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757692/pdf/MSI2016-6527458.pdf
  4. http://www.ncbi.nlm.nih.gov/pubmed/26750124
  5. http://rheumatology.oxfordjournals.org/content/early/2016/01/12/rheumatology.kev404.full.pdf
  6. http://www.ncbi.nlm.nih.gov/pubmed/25583837
  7. http://www.ncbi.nlm.nih.gov/pubmed/25691380
  8. http://www.ncbi.nlm.nih.gov/pubmed/24684929
  9. http://www.ncbi.nlm.nih.gov/pubmed/24261425
  10. http://www.ncbi.nlm.nih.gov/pubmed/22018758
  11. http://www.ncbi.nlm.nih.gov/pubmed/21371350
  12. http://www.ncbi.nlm.nih.gov/pubmed/21122553
  13. http://ecco-jcc.oxfordjournals.org/content/eccojc/4/5/493.full.pdf
  14. http://www.ncbi.nlm.nih.gov/pubmed/20671559
  15. http://www.ncbi.nlm.nih.gov/pubmed/21172284
  16. http://download.journals.elsevierhealth.com/pdfs/journals/1873-9946/PIIS1873994609000269.pdf
  17. http://www.ncbi.nlm.nih.gov/pubmed/19170693
  18. http://www.ncbi.nlm.nih.gov/pubmed/18166549
  19. http://pediatrics.aappublications.org/content/121/1/e92.full.pdf
  20. http://www.ncbi.nlm.nih.gov/pubmed/17661756
  21. http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2007.03397.x/epdf
  22. http://www.ncbi.nlm.nih.gov/pubmed/17599074
  23. http://www.ncbi.nlm.nih.gov/pubmed/18239407
  24. http://www.ncbi.nlm.nih.gov/pubmed/16409012
  25. http://www.nhlbi.nih.gov/health/prof/lung/asthma/astpreg/astpreg_qr.pdf
  26. http://www.nhlbi.nih.gov/health/prof/lung/asthma/astpreg/astpreg_full.pdf
  27. http://www.ncbi.nlm.nih.gov/pubmed/12829927
  28. http://www.ncbi.nlm.nih.gov/pubmed/11901392
  29. http://www.ncbi.nlm.nih.gov/pubmed/11336764
  30. http://www.ncbi.nlm.nih.gov/pubmed/11726078
  31. http://www.ncbi.nlm.nih.gov/pubmed/10724046
  32. http://archinte.jamanetwork.com/data/Journals/INTEMED/11959/ira90005.pdf
  33. http://www.ncbi.nlm.nih.gov/pubmed/9458024
  34. http://www.ncbi.nlm.nih.gov/pubmed/23282454
  35. http://www.ncbi.nlm.nih.gov/pubmed/2364575
  36. http://www.ncbi.nlm.nih.gov/pubmed/3893608

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