Recommendations made
pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.
Is it allowed to take Thiamazole during lactation? |
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Excretion into breast milk is insignificant (Low 1979, Teller 1980).No adverse effects reported in breastfed infants (Rylance 1987). Plasma levels in those infants were shown to be low or undetectable (Azizi 2002-2003). Maternal daily dose as high as 20 - 30 mg has shown to be safe for the intant at short and long term with normal serum levels of T3, T4, TSH and psychomotor development that make routine blood test controls unnecessary (Lamberg 1984, Cooper 1987, Rylance 1987, Azizi 1996, 2000, 2002, 2003 y 2006, Mandel 2001, Bartalena 2005, Marx 2008, Inoue 2009, Glatstein 2009, Stagnaro 2011, Serrano 2014, Alexander 2017). It would be advisable to take the medication immediately after the breast feed to minimize infant exposition (Hudzik 2016). Given the risk of hepatic toxicity of propylthiouracil, methimazole is considered preferential treatment for hyperthyroidism, especially during breastfeeding (Karras 2009, 2010 and 2012, Azizi 2011, Serrano 2014, Hudzik 2016). American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding (AAP 2001) |
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Types of risk
VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...
LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...
HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...
VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...
Scientific literature
The level of risk for breastfeeding is confirmed in these scientific publications:- http://www.ncbi.nlm.nih.gov/pubmed/28056690
- http://online.liebertpub.com/doi/pdf/10.1089/thy.2016.0457
- http://www.ncbi.nlm.nih.gov/pubmed/25073822
- http://www.elsevier.es/en-revista-medicina-clinica-english-edition--462-pdf-S2387020615000376-S300
- http://www.ncbi.nlm.nih.gov/pubmed/24782995
- http://www.karger.com/Article/Pdf/336595
- http://www.ncbi.nlm.nih.gov/pubmed/24782994
- http://www.karger.com/Article/Pdf/336102
- http://www.ncbi.nlm.nih.gov/pubmed/21389085
- http://www.eje-online.org/content/164/6/871.full.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/21851752
- http://www.ncbi.nlm.nih.gov/pubmed/21787128
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472679/pdf/thy.2011.0087.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/21037541
- http://www.ncbi.nlm.nih.gov/pubmed/19602653
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718594/pdf/0550701.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/19675263
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726094/pdf/0550797.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/20058397
- http://www.hormones.gr/pdf/Antithyroid%20drugs%20used%20in%20the%20treatment.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/16418686
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635531/pdf/nihms459198.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/16682838
- http://www.ncbi.nlm.nih.gov/pubmed/16886586
- http://www.ncbi.nlm.nih.gov/pubmed/15952916
- http://www.tandfonline.com/doi/pdf/10.1517/14656566.6.6.851?needAccess=true
- http://www.ncbi.nlm.nih.gov/pubmed/12841536
- http://www.ncbi.nlm.nih.gov/pubmed/14714745
- http://www.ncbi.nlm.nih.gov/pubmed/12109618
- http://www.ncbi.nlm.nih.gov/pubmed/11533352
- http://pediatrics.aappublications.org/content/108/3/776.full.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/11397822
- https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem.86.6.7573
- http://www.ncbi.nlm.nih.gov/pubmed/10999814
- https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem.85.9.6810
- http://www.ncbi.nlm.nih.gov/pubmed/10205431
- http://www.ncbi.nlm.nih.gov/pubmed/8648549
- http://www.ncbi.nlm.nih.gov/pubmed/2882332
- http://www.ncbi.nlm.nih.gov/pubmed/2441601
- http://www.ncbi.nlm.nih.gov/pubmed/6546390
- http://www.ncbi.nlm.nih.gov/pubmed/6744638
- http://www.ncbi.nlm.nih.gov/pubmed/6897386
- http://www.ncbi.nlm.nih.gov/pubmed/6172233
- http://www.ncbi.nlm.nih.gov/pubmed/6158636
- http://www.ncbi.nlm.nih.gov/pubmed/91730