Flaviviruses are mainly transmitted by the bite of Aedes mosquitoes (Ae. aegypti and Ae. albopictus or Tiger mosquito) from infected reservoirs that are mostly humans but may also be various animals. It has been documented sporadically transmission by sexual intercourse and vertically from the mother to the child (transplacental and perinatal). Ongoing research on the relationship between placental transmission and congenital microcephaly is currently held. Also of concern is a possible transmission by blood transfusion. Although RNA-particles of Zika virus have been found in breast milk, transmission of the infection through breastfeeding has not been documented. The viral infection is asymptomatic in 75% of cases. Only one out of four infected persons generally develop benign symptoms with few complications in adults and children and even infants, with rare admission of patients. Two infants had positive test for the virus, presumably after perinatal transmission, one remained asymptomatic and the other one with mild symptoms that doubtfully were due to the virus. Both, as well as their mothers evolved favorably (Besnard, 2014). Given the benefits of breastfeeding, expert committees like The Centers for Disease Control and Prevention (CDC) recommend breastfeeding even in areas where there is the presence of Zika virus.