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Recommendations made
pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.


woomen

Is it allowed to take Estradiol + Dienogest during lactation?
Is it safe for a nursing mother and a child?

Birth control pill that contains the combination of an estrogen (Estradiol valerate) and a progestin (Dienogest) for oral use. Estradiol is excreted into the breast milk in no or small amount. No problems have been observed in infants whose mothers were receiving this drug. There is evidence (albeit inconsistent) that estrogen-containing pills may decrease milk production, especially during the first few weeks postpartum with a daily dose above 30 micrograms of ethinyl estradiol.It may reduce the protein content of the milk.No problems have been observed in infants whose mothers were treated, except some cases of transient gynecomastia in infants whose mothers were receiving a higher dose than usual. Dienogest is a progestin with a similar structure as levonorgestrel. A latest update no published data on excretion into breast milk were found. Progesterone and other progestins are excreted into breast milk in clinically non-significant amount and no problems have been observed in infants whose mothers were treated. Plasma levels in these infants were usually very low. With other similar combined contraceptives no differences have been observed in the frequency of breastfeeding or the amount of milk produced or weight gain of breastfed infants compared to other contraceptive methods (intrauterine devices, isolated progestogens). However, it would be advisable to avoid them until breastfeeding is well established (4-6 weeks). During lactation, progestin-only contraceptive pills are preferred to Estrogen containing ones, otherwise, the lowest estrogen dose should be used.Within the first 6 postpartum weeks, non-hormonal methods are in the first line of choice. Hormone containing contraceptives do not affect the composition of milk, minerals (Mg, Fe, Cu, Ca, P) fat, lactose and calories but only a few the proteins.

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woomen

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Types of risk

VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...

LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...

HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...

VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...

Trade Names

The main trade names in different countries containing in its composition Estradiol + Dienogest:

Scientific literature

The level of risk for breastfeeding is confirmed in these scientific publications:
  1. http://www.ncbi.nlm.nih.gov/pubmed/25793657
  2. http://www.ncbi.nlm.nih.gov/pubmed/26002804
  3. http://www.ncbi.nlm.nih.gov/pubmed/26390248
  4. http://www.ncbi.nlm.nih.gov/pubmed/25551519
  5. https://abm.memberclicks.net/assets/DOCUMENTS/PROTOCOLS/13-contraception-and-breastfeeding-protocol-english.pdf
  6. https://abm.memberclicks.net/assets/DOCUMENTS/PROTOCOLS/13-contraception-and-breastfeeding-protocol-spanish.pdf
  7. http://www.ncbi.nlm.nih.gov/pubmed/26447268
  8. http://www.ncbi.nlm.nih.gov/pubmed/25956588
  9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641053/pdf/nihms-689490.pdf
  10. http://www.ncbi.nlm.nih.gov/pubmed/23623474
  11. http://www.fertstert.org/article/S0015-0282(13)00455-X/pdf
  12. http://www.ncbi.nlm.nih.gov/pubmed/23635040
  13. http://www.ncbi.nlm.nih.gov/pubmed/23784109
  14. http://www.cdc.gov/mmwr/pdf/rr/rr6205.pdf
  15. http://www.ncbi.nlm.nih.gov/pubmed/24491602
  16. http://www.ncbi.nlm.nih.gov/pubmed/22682722
  17. http://www.ncbi.nlm.nih.gov/pubmed/22143258
  18. http://www.ncbi.nlm.nih.gov/pubmed/20559203
  19. http://www.cdc.gov/mmwr/pdf/rr/rr5904.pdf
  20. http://www.ncbi.nlm.nih.gov/pubmed/21080791
  21. http://www.ncbi.nlm.nih.gov/pubmed/19637436
  22. http://www.ncbi.nlm.nih.gov/pubmed/16531169
  23. http://www.ncbi.nlm.nih.gov/pubmed/11861054
  24. http://www.ncbi.nlm.nih.gov/pubmed/11172794
  25. http://www.ncbi.nlm.nih.gov/pubmed/7924322
  26. http://www.ncbi.nlm.nih.gov/pubmed/7924321
  27. http://www.ncbi.nlm.nih.gov/pubmed/6241559
  28. http://www.ncbi.nlm.nih.gov/pubmed/7361700
  29. http://ajcn.nutrition.org/content/33/4/816.full.pdf
  30. http://www.ncbi.nlm.nih.gov/pubmed/717472

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