Is it allowed to take Flunarizine Hydrochloride during lactation? |
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Calcium-channel-blocking drug which is a piperazine derivative antihistamine with sedative effects.Used in prophylaxis of migraines and dizziness. At latest update no published data on excretion into breast milk were found.It may increase prolactin level (from Cortelli Formisano 1985 to 1991).Despite its high protein-binding capacity, because of a very long half-life span (18 days), there is a higher risk of excretion into breastmilk. A known and safer alternative should be preferred until more published data on this drug related to breastfeeding is available, - e.g. Propranolol, Metoprolol, Sertraline, Escitalopram, Amitrptilina or Valproate for Migraine prophylaxis (Pringsheim 2012, Davanzo 2014) and Nimodipine, Betahistine or Ginkgo biloba for vertigo prophylaxis, especially in the neonatal period and in case of prematurity. |
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Types of risk
VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...
LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...
HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...
VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...
Analogues
Trade Names
The main trade names in different countries containing in its composition Flunarizine Hydrochloride:Scientific literature
The level of risk for breastfeeding is confirmed in these scientific publications:- http://www.ncbi.nlm.nih.gov/pubmed/25217187
- http://www.ncbi.nlm.nih.gov/pubmed/22683887
- http://www.ncbi.nlm.nih.gov/pubmed/15120099
- http://www.ncbi.nlm.nih.gov/pubmed/1782981
- http://www.ncbi.nlm.nih.gov/pubmed/3139830
- http://www.ncbi.nlm.nih.gov/pubmed/3133923
- http://www.ncbi.nlm.nih.gov/pubmed/3113975
- http://www.ncbi.nlm.nih.gov/pubmed/3160473
- http://www.ncbi.nlm.nih.gov/pubmed/4016933
- http://www.ncbi.nlm.nih.gov/pubmed/6833428
- http://www.ncbi.nlm.nih.gov/pubmed/7142341