Azathioprine

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Doctor

Recommendations made
pediatrician - Dr. Victоr Аbdоw
Rоckville, МD, USА.

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Is it allowed to take Azathioprine during lactation?
Is it safe for a nursing mother and a child?

Even though it is metabolized to mercaptopurine, just tiny amounts of this drug have been found in breast milk (4 - 18 micrograms/liter). Among several breastfed infants of mothers who were treated with Azathioprine failed to be detected in the blood nor side effects were found. Long-term infectious diseases were not more common among exposed infants. Exposition would be minimized if nursing is resumed 3 hours after last dose.

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Types of risk

VERY LOW RISK
It is allowed while breastfeeding. It is not dangerous for a baby. It is moderately safe. more...

LOW RISK PROBABLE
Possible presence in breast milk is allowed. Follow the doctor's recommendation. more...

HIGH RISK PROBABLE
An unsafe drug, it is necessary to assess the risks while taking. Use safer analogs. more...

VERY HIGH RISK
It is not recommended. You need to stop breastfeeding or choose a safe analog. more...

Trade Names

The main trade names in different countries containing in its composition Azathioprine:

Scientific literature

The level of risk for breastfeeding is confirmed in these scientific publications:
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  4. http://ard.bmj.com/content/early/2016/02/17/annrheumdis-2015-208840.full.pdf
  5. http://www.ncbi.nlm.nih.gov/pubmed/27027799
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860651/pdf/bfm.2016.0042.pdf
  7. http://www.ncbi.nlm.nih.gov/pubmed/26688268
  8. http://www.gastrojournal.org/article/S0016-5085(15)01773-4/pdf
  9. http://www.ncbi.nlm.nih.gov/pubmed/26888577
  10. http://www.ncbi.nlm.nih.gov/pubmed/26966579
  11. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757692/pdf/MSI2016-6527458.pdf
  12. http://www.ncbi.nlm.nih.gov/pubmed/27760078
  13. http://www.zora.uzh.ch/id/eprint/134470/1/134470.pdf
  14. http://www.ncbi.nlm.nih.gov/pubmed/26115649
  15. http://www.ncbi.nlm.nih.gov/pubmed/24614280
  16. http://www.ncbi.nlm.nih.gov/pubmed/24528912
  17. http://www.ncbi.nlm.nih.gov/pubmed/24707132
  18. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974516/pdf/WJG-20-3495.pdf
  19. http://www.ncbi.nlm.nih.gov/pubmed/25200000
  20. http://onlinelibrary.wiley.com/doi/10.1111/apt.12949/epdf
  21. http://www.ncbi.nlm.nih.gov/pubmed/25271063
  22. http://www.ncbi.nlm.nih.gov/pubmed/23474350
  23. http://www.dldjournalonline.com/article/S1590-8658(13)00050-9/pdf
  24. http://www.ncbi.nlm.nih.gov/pubmed/23749699
  25. http://medwiekurozwoj.pl/articles/2013-1-10.pdf
  26. http://onlinelibrary.wiley.com/doi/10.1111/fcp.12025/abstract
  27. http://www.ncbi.nlm.nih.gov/pubmed/22690068
  28. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369996/pdf/WJG-18-2600.pdf
  29. http://www.ncbi.nlm.nih.gov/pubmed/22221203
  30. http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2011.04967.x/epdf
  31. http://www.ncbi.nlm.nih.gov/pubmed/22309336
  32. http://www.ncbi.nlm.nih.gov/pubmed/22387837
  33. http://pdf.medrang.co.kr/Kjg/059/Kjg059-02-05.pdf
  34. http://www.ncbi.nlm.nih.gov/pubmed/21985166
  35. http://www.ncbi.nlm.nih.gov/pubmed/21453877
  36. http://www.ncbi.nlm.nih.gov/pubmed/21371350
  37. http://www.ncbi.nlm.nih.gov/pubmed/19885906
  38. http://www.ncbi.nlm.nih.gov/pubmed/21122553
  39. http://ecco-jcc.oxfordjournals.org/content/eccojc/4/5/493.full.pdf
  40. http://www.ncbi.nlm.nih.gov/pubmed/21122490
  41. http://www.ncbi.nlm.nih.gov/pubmed/28839543
  42. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517153/pdf/flgastro-2009-000174.pdf
  43. http://www.ncbi.nlm.nih.gov/pubmed/21172284
  44. http://download.journals.elsevierhealth.com/pdfs/journals/1873-9946/PIIS1873994609000269.pdf
  45. http://www.ncbi.nlm.nih.gov/pubmed/19566905
  46. http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2009.03996.x/epdf
  47. http://www.ncbi.nlm.nih.gov/pubmed/18799245
  48. http://www.ncbi.nlm.nih.gov/pubmed/18761704
  49. http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2008.03843.x/epdf
  50. http://www.ncbi.nlm.nih.gov/pubmed/17599074
  51. http://www.ncbi.nlm.nih.gov/pubmed/18239407
  52. http://www.ncbi.nlm.nih.gov/pubmed/17261122
  53. http://onlinelibrary.wiley.com/doi/10.1111/j.1471-0528.2006.01232.x/epdf
  54. http://www.ncbi.nlm.nih.gov/pubmed/17389671
  55. http://www.ncbi.nlm.nih.gov/pubmed/17661756
  56. http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2007.03397.x/epdf
  57. http://www.ncbi.nlm.nih.gov/pubmed/16995866
  58. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885151/pdf/bcp0062-0453.pdf
  59. http://www.ncbi.nlm.nih.gov/pubmed/17132809
  60. http://www.ncbi.nlm.nih.gov/pubmed/16831611
  61. http://www.gastrojournal.org/article/S0016-5085(06)00865-1/pdf
  62. http://www.ncbi.nlm.nih.gov/pubmed/16712713
  63. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1526635/pdf/ar1957.pdf
  64. http://www.ncbi.nlm.nih.gov/pubmed/16194696
  65. http://whqlibdoc.who.int/hq/2002/55732.pdf
  66. http://www.ncbi.nlm.nih.gov/pubmed/12091650
  67. http://ndt.oxfordjournals.org/content/17/suppl_4/50.full.pdf
  68. http://www.ncbi.nlm.nih.gov/pubmed/11013791
  69. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2145042/pdf/canfamphys00031-0055.pdf
  70. http://www.ncbi.nlm.nih.gov/pubmed/10724046
  71. http://archinte.jamanetwork.com/data/Journals/INTEMED/11959/ira90005.pdf
  72. http://www.ncbi.nlm.nih.gov/pubmed/9458024
  73. http://www.ncbi.nlm.nih.gov/pubmed/23282454
  74. http://www.ncbi.nlm.nih.gov/pubmed/6371564
  75. http://www.ncbi.nlm.nih.gov/pubmed/6817481

Comments  

+3 #3 Reviewer: 35-44 Female on Treatment for less than 1 month (Caregiver) 2019-04-18 08:09
Is this drug safe to an unborn fetus?
+3 #2 Reviewer: Dom, 35-44 Female on Treatment for 10 years or more (Patient) 2019-03-10 09:04
I have had ulcerative colitis for almost 18 years. This drug, combined with asacol, is the only thing that has kept me alive. I have been on 150 mg a day for over 10 years. Because of this drug, I have been in remission for close to 9 years with an excellent quality of life.
+3 #1 Reviewer: 45-54 Female on Treatment for 6 months to less than 1 year (Patient) 2019-02-28 07:30
Have pan colitis, prednisone dependent, taking aza.for 6 months. Started on 25 mg. low dose due to low tmpt, no help, increased to 50 mg. greatly reduced symptoms, ready to increase, but now have high liver enzyme (alkaline phosphate). Doing full liver function panel and ultrasound of liver. Discussed biologics next. Advise everyone with IBD to see an IBD specialist along with gastro.

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