Prostaglandin E2 is eventually used for induction of labor at term. Orally or vaginally administrated. At latest update no published data on excretion into breast milk were found.Pharmacokinetic data (very rapid removal and moderately high protein binding capacity) make it highly unlikely the passage into breast milk in significant amounts.It is a natural component of breast milk (Alzina 1986 Neu 1988) that increases in concentration in the first week postpartum (Hawkes 1999) and possibly plays an important role in the gastrointestinal function of the infant (Bedrick 1989, Shimizu 1992) and intestinal motility (Lucas 1980, Li 1994). Although dinoprostone can be used to inhibit lactation by reducing prolactin levels (Bremme 1980, England 1988, Toppozada 1992), it would be necessary to achieve a higher dose than that used at the time of partum for several days (Berić 1992). It would not be recommended to use it for relief of breast engorgement in women who are willing to breastfeed.The effect of reducing prolactin levels induced by dinoprostone only occurs during the first days postpartum (Caminiti 1980).